PMID- 27566192
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20211204
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 32
IP  - 12
DP  - 2016 Dec
TI  - Cardiac magnetic resonance and galectin-3 level as predictors of prognostic 
      outcomes for non-ischemic cardiomyopathy patients.
PG  - 1725-1733
AB  - This study was aimed at determining whether late gadolinium enhancement (LGE) in 
      conjunction with Galectin-3 (Gal-3) level offered more precise prognosis of 
      non-ischemic cardiomyopathy (NICM) in comparison to LGE alone. Results of LGE and 
      Gal-3 expression in 192 patients with NICM, including 85 subjects with dilated 
      cardiomyopathy (DCM) and 107 with hypertrophic cardiomyopathy (HCM), were 
      examined. As suggested by the characteristics of LGE and Gal-3 levels, patients 
      were divided into four groups: LGE positive + low Gal-3 (n = 10 for DCM, n = 15 
      for HCM), LGE positive + high Gal-3 (n = 25 for DCM, n = 51 for HCM), LGE 
      negative + low Gal-3 (n = 32 for DCM, n = 29 for HCM), LGE negative + high Gal-3 
      (n = 18 for DCM, n = 12 for HCM). Primary endpoints over the follow-up period 
      included major adverse cardiac events (MACEs). Kaplan-Meier survival analysis and 
      univariate Cox proportional hazard models were used to analyze the survival 
      status of patients with NICM. The optimal cut-off value of Gal-3 level for two 
      types of NICM was determined by receiver operating characteristic analysis 
      (13.38 U/L for DCM and 14.40 U/L for HCM). The combination of LGE and Gal-3 
      levels offered a more significant prognostic value than using LGE alone for both 
      DCM and HCM (DCM P = 0.001 < 0.012; HCM P = 0.037 < 0.040). Moreover, the Cox 
      proportional hazard model suggested that both LGE status [Hazard ratio 
      (HR) = 2.62, P = 0.017] and Gal-3 level (HR = 1.16, P = 0.013) were significant 
      predictors of MACEs in DCM, while they did not appear to have significant 
      prognostic values for HCM (P = 0.06 and 0.64). Furthermore, the multivariate 
      analysis only confirmed LGE as an independent element in predicting prognosis of 
      DCM (HR = 12.19, P = 0.026). In conclusion, LGE status was an independent 
      indicator of DCM prognosis, yet the insignificant role of LGE in HCM prognosis 
      could be limited by sample size.
FAU - Hu, Da-Jun
AU  - Hu DJ
AD  - Department of Cardiology, the First Hospital of Chenzhou, Luojiajing No.102, Bei 
      huCounty, Chenzhou, Hunan, 423000, People's Republic of China. liulidr@126.com.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Cardiology, the First Hospital of Chenzhou, Luojiajing No.102, Bei 
      huCounty, Chenzhou, Hunan, 423000, People's Republic of China.
FAU - Du, Wei
AU  - Du W
AD  - Department of Cardiology, the First Hospital of Chenzhou, Luojiajing No.102, Bei 
      huCounty, Chenzhou, Hunan, 423000, People's Republic of China.
FAU - Zhang, Jian-Xin
AU  - Zhang JX
AD  - Department of Cardiology, the First Hospital of Chenzhou, Luojiajing No.102, Bei 
      huCounty, Chenzhou, Hunan, 423000, People's Republic of China.
FAU - Zhong, Min
AU  - Zhong M
AD  - Department of Cardiology, the First Hospital of Chenzhou, Luojiajing No.102, Bei 
      huCounty, Chenzhou, Hunan, 423000, People's Republic of China.
FAU - Zhou, Ya-Nan
AU  - Zhou YN
AD  - Department of Cardiology, the First Hospital of Chenzhou, Luojiajing No.102, Bei 
      huCounty, Chenzhou, Hunan, 423000, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160826
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Biomarkers)
RN  - 0 (Blood Proteins)
RN  - 0 (Contrast Media)
RN  - 0 (Galectin 3)
RN  - 0 (Galectins)
RN  - 0 (LGALS3 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Blood Proteins
MH  - Cardiomyopathy, Dilated/*blood/*diagnostic imaging/mortality/physiopathology
MH  - Cardiomyopathy, Hypertrophic/*blood/*diagnostic imaging/mortality/physiopathology
MH  - Chi-Square Distribution
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Galectin 3/*blood
MH  - Galectins
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Up-Regulation
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Dilated cardiomyopathy
OT  - Galectin-3
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Major adverse cardiac events
OT  - Non-ischemic cardiomyopathy
OT  - Prognosis
EDAT- 2016/08/28 06:00
MHDA- 2017/04/25 06:00
CRDT- 2016/08/28 06:00
PHST- 2016/06/05 00:00 [received]
PHST- 2016/08/05 00:00 [accepted]
PHST- 2016/08/28 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2016/08/28 06:00 [entrez]
AID - 10.1007/s10554-016-0958-1 [pii]
AID - 10.1007/s10554-016-0958-1 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2016 Dec;32(12):1725-1733. doi: 
      10.1007/s10554-016-0958-1. Epub 2016 Aug 26.