PMID- 27566288
OWN - NLM
STAT- MEDLINE
DCOM- 20170601
LR  - 20181113
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 152
DP  - 2017 Jan
TI  - Sex differences in abuse-related neurochemical and behavioral effects of 
      3,4-methylenedioxymethamphetamine (MDMA) in rats.
PG  - 52-60
LID - S0091-3057(16)30140-X [pii]
LID - 10.1016/j.pbb.2016.08.004 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a substrate for dopamine (DA), 
      norepinephrine and serotonin (5HT) transporters that produces greater 
      pharmacological effects on certain endpoints in females than males in both 
      clinical and rodent preclinical studies. To evaluate potential for sex 
      differences in abuse-related MDMA effects, the present study compared MDMA 
      effects on intracranial self-stimulation (ICSS) and on in vivo microdialysis 
      measurements of DA or 5HT in the nucleus accumbens (NAc) in female and male 
      Sprague-Dawley rats. For ICSS studies, electrodes were implanted in the medial 
      forebrain bundle and rats trained to press for electrical stimulation over a 
      range of frequencies (56-158Hz, 0.05 log increments) under a fixed-ratio 1 
      schedule, and the potency (0.32-3.2mg/kg, 10min pretreatment) and time course 
      (3.2. mg/kg, 10-180min pretreatment) of MDMA effects were determined. For in vivo 
      microdialysis, rats were implanted with bilateral guide cannulae targeting the 
      NAc, and the time course of MDMA effects (1.0-3.2mg/kg, 0-180min) on DA and 5HT 
      was determined. MDMA produced qualitatively similar effects in both sexes on ICSS 
      (both increases in low ICSS rates maintained by low brain-stimulation frequencies 
      and decreases in high ICSS rates maintained by high brain-stimulation 
      frequencies) and microdialysis (increases in both DA and 5HT). The duration and 
      peak levels of both abuse-related ICSS facilitation and increases in NAc DA were 
      longer in females. MDMA was also more potent to increase 5HT in females. These 
      results provide evidence for heightened sensitivity of females to abuse-related 
      behavioral and neurochemical effects of MDMA in rats.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Lazenka, M F
AU  - Lazenka MF
AD  - Department of Pharmacology and Toxicology, Virginia Commonwealth University, 
      Richmond, VA 23298, USA. Electronic address: lazenkamf@mymail.vcu.edu.
FAU - Suyama, J A
AU  - Suyama JA
AD  - Department of Pharmacology and Toxicology, Virginia Commonwealth University, 
      Richmond, VA 23298, USA.
FAU - Bauer, C T
AU  - Bauer CT
AD  - Department of Pharmacology and Toxicology, Virginia Commonwealth University, 
      Richmond, VA 23298, USA.
FAU - Banks, M L
AU  - Banks ML
AD  - Department of Pharmacology and Toxicology, Virginia Commonwealth University, 
      Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia 
      Commonwealth University, Richmond, VA 23298, USA.
FAU - Negus, S S
AU  - Negus SS
AD  - Department of Pharmacology and Toxicology, Virginia Commonwealth University, 
      Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia 
      Commonwealth University, Richmond, VA 23298, USA.
LA  - eng
GR  - P30 DA033934/DA/NIDA NIH HHS/United States
GR  - R01 DA026946/DA/NIDA NIH HHS/United States
GR  - R01 DA033930/DA/NIDA NIH HHS/United States
GR  - T32 DA007027/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20160824
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Male
MH  - Medial Forebrain Bundle/physiology
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Nucleus Accumbens/metabolism
MH  - Rats
MH  - Self Stimulation/drug effects
MH  - Serotonin/metabolism
MH  - *Sex Characteristics
MH  - Time Factors
PMC - PMC5195862
MID - NIHMS813382
OTO - NOTNLM
OT  - ICSS
OT  - MDMA
OT  - Microdialysis
OT  - Sex difference
EDAT- 2016/08/28 06:00
MHDA- 2017/06/02 06:00
PMCR- 2018/01/01
CRDT- 2016/08/28 06:00
PHST- 2016/06/09 00:00 [received]
PHST- 2016/08/13 00:00 [revised]
PHST- 2016/08/22 00:00 [accepted]
PHST- 2016/08/28 06:00 [pubmed]
PHST- 2017/06/02 06:00 [medline]
PHST- 2016/08/28 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - S0091-3057(16)30140-X [pii]
AID - 10.1016/j.pbb.2016.08.004 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2017 Jan;152:52-60. doi: 10.1016/j.pbb.2016.08.004. Epub 
      2016 Aug 24.