PMID- 27567155
OWN - NLM
STAT- MEDLINE
DCOM- 20170307
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 163
DP  - 2016 Nov
TI  - Gestational and lactational exposure to bisphenol AF in maternal rats increases 
      testosterone levels in 23-day-old male offspring.
PG  - 552-561
LID - S0045-6535(16)31077-3 [pii]
LID - 10.1016/j.chemosphere.2016.08.059 [doi]
AB  - During prenatal and postnatal development, exposure to environmental chemicals 
      with estrogenic activity, such as bisphenol AF (BPAF), may result in reproductive 
      disorders. Currently, the mechanisms behind such disorders in male offspring 
      induced by gestational and lactational exposure to BPAF remain poorly understood. 
      Here, female rats from gestational day (GD) 3-19 were exposed to 100 mg 
      BPAF/kg/day by oral gavage. On the day of birth (postnatal day (PD) 0), 
      cross-fostering took place between treated and control litters, and 
      cross-fostered mother rats were given BPAF 100 mg/kg/day during the postnatal 
      period (PD 3 to PD 19). HPLC-MS/MS analysis showed that BPAF was transferred via 
      cord blood and lactation, finally bio-accumulating in the offspring testes. Pups 
      exposed to BPAF both prenatally and postnatally showed a significant increase in 
      testis testosterone levels compared with that of the control, while all pups 
      exposed to BPAF showed a significant decrease in testis inhibin B (INHB) levels. 
      Compared with the control, RNA-seq revealed that 279 genes were significantly 
      differentially expressed in the testes of pups exposed to BPAF both prenatally 
      and postnatally, including genes involved in cell differentiation and meiosis. 
      These results indicate that gestational and lactational exposure to BPAF in the 
      mother can impair reproductive function in male offspring.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Li, Jing
AU  - Li J
AD  - Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, 100101, PR China.
FAU - Sheng, Nan
AU  - Sheng N
AD  - Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, 100101, PR China.
FAU - Cui, Ruina
AU  - Cui R
AD  - Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, 100101, PR China.
FAU - Feng, Yixing
AU  - Feng Y
AD  - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food 
      Poisoning, Beijing Centre for Disease Control and Prevention, Beijing, 100013, PR 
      China.
FAU - Shao, Bing
AU  - Shao B
AD  - Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food 
      Poisoning, Beijing Centre for Disease Control and Prevention, Beijing, 100013, PR 
      China.
FAU - Guo, Xuejiang
AU  - Guo X
AD  - State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 
      Nanjing, 210029, PR China.
FAU - Zhang, Hongxia
AU  - Zhang H
AD  - Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, 100101, PR China.
FAU - Dai, Jiayin
AU  - Dai J
AD  - Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, 
      Chinese Academy of Sciences, Beijing, 100101, PR China. Electronic address: 
      daijy@ioz.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20160825
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Phenols)
RN  - 3XMK78S47O (Testosterone)
RN  - OH7IX8A37J (4,4'-hexafluorisopropylidene diphenol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Benzhydryl Compounds/*adverse effects/blood
MH  - Biological Assay
MH  - Blotting, Western
MH  - Breast Feeding
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Lactation/*drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Phenols/*adverse effects/blood
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction
MH  - Tandem Mass Spectrometry
MH  - Testis/*drug effects/metabolism
MH  - Testosterone/*metabolism
OTO - NOTNLM
OT  - Bisphenol A
OT  - Bisphenol AF
OT  - Endocrine-disrupting compounds (EDCs)
OT  - RNA-seq
OT  - Reproductive toxicity
OT  - Testicular function
EDAT- 2016/08/28 06:00
MHDA- 2017/03/08 06:00
CRDT- 2016/08/28 06:00
PHST- 2016/06/26 00:00 [received]
PHST- 2016/08/05 00:00 [revised]
PHST- 2016/08/12 00:00 [accepted]
PHST- 2016/08/28 06:00 [entrez]
PHST- 2016/08/28 06:00 [pubmed]
PHST- 2017/03/08 06:00 [medline]
AID - S0045-6535(16)31077-3 [pii]
AID - 10.1016/j.chemosphere.2016.08.059 [doi]
PST - ppublish
SO  - Chemosphere. 2016 Nov;163:552-561. doi: 10.1016/j.chemosphere.2016.08.059. Epub 
      2016 Aug 25.