PMID- 27568549
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20220409
IS  - 1932-7420 (Electronic)
IS  - 1550-4131 (Linking)
VI  - 24
IP  - 3
DP  - 2016 Sep 13
TI  - Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 
      Immune Signaling.
PG  - 434-446
LID - S1550-4131(16)30374-6 [pii]
LID - 10.1016/j.cmet.2016.07.023 [doi]
AB  - Caloric restriction (CR) extends lifespan from yeast to mammals, delays onset of 
      age-associated diseases, and improves metabolic health. We show that CR 
      stimulates development of functional beige fat within the subcutaneous and 
      visceral adipose tissue, contributing to decreased white fat and adipocyte size 
      in lean C57BL/6 and BALB/c mice kept at room temperature or at thermoneutrality 
      and in obese leptin-deficient mice. These metabolic changes are mediated by 
      increased eosinophil infiltration, type 2 cytokine signaling, and M2 macrophage 
      polarization in fat of CR animals. Suppression of the type 2 signaling, using 
      Il4ra(-/-), Stat6(-/-), or mice transplanted with Stat6(-/-) bone marrow-derived 
      hematopoietic cells, prevents the CR-induced browning and abrogates the 
      subcutaneous fat loss and the metabolic improvements induced by CR. These results 
      provide insights into the overall energy homeostasis during CR, and they suggest 
      beige fat development as a common feature in conditions of negative energy 
      balance.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Fabbiano, Salvatore
AU  - Fabbiano S
AD  - Department of Cell Physiology and Metabolism, Centre Medical Universitaire (CMU), 
      Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
FAU - Suarez-Zamorano, Nicolas
AU  - Suarez-Zamorano N
AD  - Department of Cell Physiology and Metabolism, Centre Medical Universitaire (CMU), 
      Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
FAU - Rigo, Dorothee
AU  - Rigo D
AD  - Department of Cell Physiology and Metabolism, Centre Medical Universitaire (CMU), 
      Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
FAU - Veyrat-Durebex, Christelle
AU  - Veyrat-Durebex C
AD  - Department of Cell Physiology and Metabolism, Centre Medical Universitaire (CMU), 
      Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
FAU - Stevanovic Dokic, Ana
AU  - Stevanovic Dokic A
AD  - Department of Cell Physiology and Metabolism, Centre Medical Universitaire (CMU), 
      Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
FAU - Colin, Didier J
AU  - Colin DJ
AD  - Centre for BioMedical Imaging (CIBM), University Hospitals of Geneva, 1211 
      Geneva, Switzerland.
FAU - Trajkovski, Mirko
AU  - Trajkovski M
AD  - Department of Cell Physiology and Metabolism, Centre Medical Universitaire (CMU), 
      Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes 
      Centre, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; 
      Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 
      Geneva, Switzerland. Electronic address: mirko.trajkovski@unige.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160825
PL  - United States
TA  - Cell Metab
JT  - Cell metabolism
JID - 101233170
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue, Beige/metabolism
MH  - Adipose Tissue, Brown/*metabolism
MH  - Adipose Tissue, White/*metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Diet
MH  - Feeding Behavior
MH  - Glucose/metabolism
MH  - *Immunity
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Signal Transduction/*immunology
MH  - Subcutaneous Fat/metabolism
MH  - Thermogenesis
EDAT- 2016/08/30 06:00
MHDA- 2017/06/27 06:00
CRDT- 2016/08/30 06:00
PHST- 2016/02/26 00:00 [received]
PHST- 2016/06/22 00:00 [revised]
PHST- 2016/07/26 00:00 [accepted]
PHST- 2016/08/30 06:00 [entrez]
PHST- 2016/08/30 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
AID - S1550-4131(16)30374-6 [pii]
AID - 10.1016/j.cmet.2016.07.023 [doi]
PST - ppublish
SO  - Cell Metab. 2016 Sep 13;24(3):434-446. doi: 10.1016/j.cmet.2016.07.023. Epub 2016 
      Aug 25.