PMID- 27570526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160829
LR  - 20181113
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 7
DP  - 2016
TI  - Donor-Specific Anti-HLA Antibodies in Allogeneic Hematopoietic Stem Cell 
      Transplantation.
PG  - 307
LID - 10.3389/fimmu.2016.00307 [doi]
LID - 307
AB  - Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative 
      treatment for a wide variety of hematological diseases. In 30% of the cases, a 
      geno-identical donor is available. Any other situation displays some level of 
      human leukocyte antigen (HLA) incompatibility between donor and recipient. 
      Deleterious effects of anti-HLA immunization have long been recognized in solid 
      organ transplant recipients. More recently, anti-HLA immunization was shown to 
      increase the risk of primary graft failure (PGF), a severe complication of AHSCT 
      that occurs in 3-4% of matched unrelated donor transplantation and up to 15% in 
      cord blood transplantation and T-cell depleted haplo-identical stem cell 
      transplantation. Rates of PGF in patients with DSA were reported to be between 24 
      and 83% with the highest rates in haplo-identical and cord blood transplantation 
      recipients. This led to the recommendation of anti-HLA antibody screening to 
      detect donor-specific antibodies (DSA) in recipients prior to AHSCT. In this 
      review, we highlight the role of anti-HLA antibodies in AHSCT and the mechanisms 
      that may lead to PGF in patients with DSA, and discuss current issues in the 
      field.
FAU - Morin-Zorman, Sarah
AU  - Morin-Zorman S
AD  - Laboratoire d'Immunologie et Histocompatibilite, Hopital Saint-Louis, Assistance 
      Publique Hopitaux de Paris (APHP), Universite Paris Diderot , Paris , France.
FAU - Loiseau, Pascale
AU  - Loiseau P
AD  - Laboratoire d'Immunologie et Histocompatibilite, Hopital Saint-Louis, Assistance 
      Publique Hopitaux de Paris (APHP), Universite Paris Diderot , Paris , France.
FAU - Taupin, Jean-Luc
AU  - Taupin JL
AD  - Laboratoire d'Immunologie et Histocompatibilite, Hopital Saint-Louis, Assistance 
      Publique Hopitaux de Paris (APHP), Universite Paris Diderot , Paris , France.
FAU - Caillat-Zucman, Sophie
AU  - Caillat-Zucman S
AD  - Laboratoire d'Immunologie et Histocompatibilite, Hopital Saint-Louis, Assistance 
      Publique Hopitaux de Paris (APHP), Universite Paris Diderot , Paris , France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160812
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4981597
OTO - NOTNLM
OT  - HLA antigens
OT  - allogeneic hematopoietic stem cell transplantation
OT  - donor-specific antibodies
OT  - graft failure
OT  - single antigen flow bead assay
EDAT- 2016/08/30 06:00
MHDA- 2016/08/30 06:01
PMCR- 2016/01/01
CRDT- 2016/08/30 06:00
PHST- 2016/04/26 00:00 [received]
PHST- 2016/07/28 00:00 [accepted]
PHST- 2016/08/30 06:00 [entrez]
PHST- 2016/08/30 06:00 [pubmed]
PHST- 2016/08/30 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2016.00307 [doi]
PST - epublish
SO  - Front Immunol. 2016 Aug 12;7:307. doi: 10.3389/fimmu.2016.00307. eCollection 
      2016.