PMID- 27572233
OWN - NLM
STAT- MEDLINE
DCOM- 20171225
LR  - 20181202
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 65
DP  - 2017 Jan
TI  - Simulation of mechanical behavior and optimization of simulated injection molding 
      process for PLA based antibacterial composite and nanocomposite bone screws using 
      central composite design.
PG  - 160-176
LID - S1751-6161(16)30265-X [pii]
LID - 10.1016/j.jmbbm.2016.08.008 [doi]
AB  - In this study, injection molding of three poly lactic acid (PLA) based bone 
      screws was simulated and optimized through minimizing the shrinkage and warpage 
      of the bone screws. The optimization was carried out by investigating the process 
      factors such as coolant temperature, mold temperature, melt temperature, packing 
      time, injection time, and packing pressure. A response surface methodology (RSM), 
      based on the central composite design (CCD), was used to determine the effects of 
      the process factors on the PLA based bone screws. Upon applying the method of 
      maximizing the desirability function, optimization of the factors gave the lowest 
      warpage and shrinkage for nanocomposite PLA bone screw (PLA9). Moreover, PLA9 has 
      the greatest desirability among the selected materials for bone screw injection 
      molding. Meanwhile, a finite element analysis (FE analysis) was also performed to 
      determine the force values and concentration points which cause yielding of the 
      screws under certain conditions. The Von-Mises stress distribution showed that 
      PLA9 screw is more resistant against the highest loads as compared to the other 
      ones. Finally, according to the results of injection molding simulations, the 
      design of experiments (DOE) and structural analysis, PLA9 screw is recommended as 
      the best candidate for the production of biomedical materials among all the three 
      types of screws.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Heidari, Behzad Shiroud
AU  - Heidari BS
AD  - Applied Science Nano Research Group, ASNARKA, P.C. 1619948753, Tehran, Iran.
FAU - Oliaei, Erfan
AU  - Oliaei E
AD  - Applied Science Nano Research Group, ASNARKA, P.C. 1619948753, Tehran, Iran.
FAU - Shayesteh, Hadi
AU  - Shayesteh H
AD  - School of Chemical Engineering, Iran University of Science and Technology, 
      Narmak, Tehran, Iran.
FAU - Davachi, Seyed Mohammad
AU  - Davachi SM
AD  - Applied Science Nano Research Group, ASNARKA, P.C. 1619948753, Tehran, Iran. 
      Electronic address: mohdvi@gmail.com.
FAU - Hejazi, Iman
AU  - Hejazi I
AD  - Applied Science Nano Research Group, ASNARKA, P.C. 1619948753, Tehran, Iran.
FAU - Seyfi, Javad
AU  - Seyfi J
AD  - Department of Chemical Engineering, Shahrood Branch, Islamic Azad University, 
      P.O. Box 36155-163, Shahrood, Iran.
FAU - Bahrami, Mozhgan
AU  - Bahrami M
AD  - Macromolecular Science and Engineering, University of Michigan, Ann Arbor, 
      Michigan 48109-2136, United States.
FAU - Rashedi, Hamid
AU  - Rashedi H
AD  - Department of Biotechnology, School of Chemical Engineering, College of 
      Engineering, University of Tehran, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160817
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Polyesters)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Anti-Bacterial Agents/*analysis
MH  - *Bone Screws
MH  - Finite Element Analysis
MH  - Nanocomposites/*analysis
MH  - Polyesters/*analysis
MH  - Stress, Mechanical
OTO - NOTNLM
OT  - Central composite design
OT  - Injection molding simulation
OT  - PLA bone screw
OT  - Shrinkage and warpage
OT  - Structural analysis
EDAT- 2016/08/31 06:00
MHDA- 2017/12/26 06:00
CRDT- 2016/08/31 06:00
PHST- 2016/05/12 00:00 [received]
PHST- 2016/08/02 00:00 [accepted]
PHST- 2016/08/31 06:00 [pubmed]
PHST- 2017/12/26 06:00 [medline]
PHST- 2016/08/31 06:00 [entrez]
AID - S1751-6161(16)30265-X [pii]
AID - 10.1016/j.jmbbm.2016.08.008 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2017 Jan;65:160-176. doi: 10.1016/j.jmbbm.2016.08.008. 
      Epub 2016 Aug 17.