PMID- 27573472
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20171222
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 34
IP  - 8
DP  - 2017 Apr 15
TI  - Effect of Internal Jugular Vein Compression on Intracranial Hemorrhage in a 
      Porcine Controlled Cortical Impact Model.
PG  - 1703-1709
LID - 10.1089/neu.2016.4648 [doi]
AB  - Internal jugular vein (IJV) compression has been shown to reduce axonal injury in 
      pre-clinical traumatic brain injury (TBI) models and clinical concussion studies. 
      However, this novel approach to prophylactically mitigating TBI through venous 
      congestion raises concerns of increasing the propensity for hemorrhage and 
      hemorrhagic propagation. This study aims to test the safety of IJV compression in 
      a large animal controlled cortical impact (CCI) injury model and the resultant 
      effects on hemorrhage. Twelve swine were randomized to placement of a bilateral 
      IJV compression collar (CCI+collar) or control/no collar (CCI) prior to CCI 
      injury. A histological grading of the extent of hemorrhage, both subarachnoid 
      (SAH) and intraparenchymal (IPH), was conducted in a blinded manner by two 
      neuropathologists. Other various measures of TBI histology were also analyzed 
      including: beta-amyloid precursor protein (beta-APP) expression, presence of 
      degenerating neurons, extent of cerebral edema, and inflammatory infiltrates. 
      Euthanized 5 h after injury, the CCI+collar animals exhibited a significant 
      reduction in total SAH (p = 0.024-0.026) and IPH scores (p = 0.03-0.05) compared 
      with the CCI animals. There was no statistically significant difference in 
      scoring for the other markers of TBI (beta-APP, neuronal degeneration, cerebral 
      edema, or inflammatory infiltration). In conclusion, IJV compression was shown to 
      reduce hemorrhage (SAH and IPH) in the porcine CCI model when applied prior to 
      injury. These results suggest the role of IJV compression for mitigation of not 
      only axonal, but also hemorrhagic injury following TBI.
FAU - Sindelar, Brian
AU  - Sindelar B
AD  - 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, 
      Illinois.
AD  - 2 Department of Neurosurgery, University of Florida , Gainesville, Florida.
FAU - Bailes, Julian
AU  - Bailes J
AD  - 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, 
      Illinois.
FAU - Sherman, Sydney
AU  - Sherman S
AD  - 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, 
      Illinois.
FAU - Finan, John
AU  - Finan J
AD  - 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, 
      Illinois.
FAU - Stone, James
AU  - Stone J
AD  - 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, 
      Illinois.
FAU - Lee, John
AU  - Lee J
AD  - 3 Department of Pathology and Laboratory Medicine, NorthShore University 
      HealthSystem , Evanston, Illinois.
FAU - Ahmadian, Saman
AU  - Ahmadian S
AD  - 3 Department of Pathology and Laboratory Medicine, NorthShore University 
      HealthSystem , Evanston, Illinois.
FAU - Zhou, Ying
AU  - Zhou Y
AD  - 4 Department of Research Institute, NorthShore University HealthSystem , 
      Evanston, Illinois.
FAU - Patel, Vimal
AU  - Patel V
AD  - 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, 
      Illinois.
FAU - Smith, David
AU  - Smith D
AD  - 5 Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161216
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
SB  - IM
MH  - Animals
MH  - *Brain Injuries, Traumatic/complications/metabolism/pathology
MH  - Cerebral Hemorrhage, Traumatic/etiology/*prevention & control
MH  - Compression Bandages
MH  - Disease Models, Animal
MH  - Female
MH  - *Jugular Veins
MH  - Random Allocation
MH  - Subarachnoid Hemorrhage, Traumatic/etiology/*prevention & control
MH  - Swine
OTO - NOTNLM
OT  - CCI
OT  - SAH
OT  - TBI
OT  - animal studies
OT  - head trauma
EDAT- 2016/08/31 06:00
MHDA- 2017/08/08 06:00
CRDT- 2016/08/31 06:00
PHST- 2016/08/31 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2016/08/31 06:00 [entrez]
AID - 10.1089/neu.2016.4648 [doi]
PST - ppublish
SO  - J Neurotrauma. 2017 Apr 15;34(8):1703-1709. doi: 10.1089/neu.2016.4648. Epub 2016 
      Dec 16.