PMID- 27574384
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160830
LR  - 20200930
IS  - 1061-1711 (Print)
IS  - 1615-5939 (Electronic)
IS  - 1061-1711 (Linking)
VI  - 25
IP  - 3
DP  - 2016 Sep
TI  - Genetic Polymorphisms Influence Cognition in Patients Undergoing Carotid 
      Interventions.
PG  - 168-73
LID - 10.1055/s-0036-1580696 [doi]
AB  - While carotid interventions help decrease the risk of stroke, nearly 40% of 
      patients experience cognitive deterioration. Genetic polymorphism in 
      apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) have been 
      implicated in cognitive impairment; however, it is unclear whether they may 
      influence cognitive changes in patients undergoing carotid intervention. In this 
      study, we seek to assess the role of genetic polymorphisms in carotid 
      intervention-related cognitive change. Polymorphisms related to cognitive 
      function were chosen for this preliminary analysis. Over 2 years, patients 
      undergoing carotid interventions were prospectively recruited. Patients underwent 
      neuropsychological testing 2 weeks prior to and at 1 month following their 
      procedure. Saliva samples were collected for genetic analysis. Logistic 
      regressions were used to identify associations between polymorphisms and 
      cognitive measures. A total of 91 patients were included; all were male with an 
      average age of 70 years. The majority of patients exhibited hypertension (95%) 
      and a history of smoking (81%). Presence of ApoE 4 allele was associated with 
      depression (p= 0.047). After correcting for age and genetic polymorphisms in BDNF 
      and serotonin transporter (5-HTT), ApoE 4 allele was associated with depression 
      (p= 0.044) and showed a trend with baseline cognitive impairment (p= 0.10). Age >/= 
      70 years was associated with baseline cognitive impairment after adjusting for 
      the three genetic polymorphisms (p= 0.03). Patients with ApoE 4 and BDNF A 
      polymorphisms performed less well on the visual and verbal memory measures, 
      respectively. Polymorphisms in ApoE and BDNF may provide insight on cognition in 
      patients undergoing carotid interventions; however, the mechanism of this 
      relationship remains unclear.
FAU - Hitchner, Elizabeth
AU  - Hitchner E
AD  - Department of Vascular Surgery, VA Palo Alto Health Care System, Palo Alto, 
      California.
FAU - Morrison, Doug
AU  - Morrison D
AD  - Department of Vascular Surgery, Stanford University, Stanford, California.
FAU - Liao, Phoebe
AU  - Liao P
AD  - Department of Psychiatry, Stanford University, Stanford, California.
FAU - Rosen, Allyson
AU  - Rosen A
AD  - Department of Psychiatry, Stanford University, Stanford, California.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Department of Vascular Surgery, VA Palo Alto Health Care System, Palo Alto, 
      California; Department of Surgery, Stanford University, Stanford, California.
LA  - eng
GR  - R01 NS070308/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20160408
PL  - United States
TA  - Int J Angiol
JT  - The International journal of angiology : official publication of the 
      International College of Angiology, Inc
JID - 9504821
PMC - PMC5001867
OTO - NOTNLM
OT  - carotid endarterectomy
OT  - carotid stenosis
OT  - carotid stent
OT  - cognition
OT  - genetic
OT  - internal carotid artery
OT  - polymorphism
EDAT- 2016/08/31 06:00
MHDA- 2016/08/31 06:01
PMCR- 2017/09/01
CRDT- 2016/08/31 06:00
PHST- 2016/08/31 06:00 [entrez]
PHST- 2016/08/31 06:00 [pubmed]
PHST- 2016/08/31 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 150106 [pii]
AID - 10.1055/s-0036-1580696 [doi]
PST - ppublish
SO  - Int J Angiol. 2016 Sep;25(3):168-73. doi: 10.1055/s-0036-1580696. Epub 2016 Apr 
      8.