PMID- 27574549
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160830
LR  - 20200929
IS  - 1948-5182 (Print)
IS  - 1948-5182 (Electronic)
VI  - 8
IP  - 22
DP  - 2016 Aug 8
TI  - Boceprevir or telaprevir in hepatitis C virus chronic infection: The Italian real 
      life experience.
PG  - 949-56
LID - 10.4254/wjh.v8.i22.949 [doi]
AB  - AIM: To check the safety and efficacy of boceprevir/telaprevir with 
      peginterferon/ribavirin for hepatitis C virus (HCV) genotype 1 in the real-world 
      settings. METHODS: This study was a non-randomized, observational, prospective, 
      multicenter. This study involved 47 centers in Italy. A database was prepared for 
      the homogenous collection of the data, was used by all of the centers for data 
      collection, and was updated continuously. All of the patients enrolled in this 
      study were older than 18 years of age and were diagnosed with chronic infection 
      due to HCV genotype 1. The HCV RNA testing was performed using COBAS-TaqMan2.0 
      (Roche, LLQ 25 IU/mL). RESULTS: All consecutively treated patients were included. 
      Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57 
      (range 18-78), of whom 18.3% were over 65; mean body mass index 25.6 (range 
      16-39); genotype 1b (79.4%); diagnosis of cirrhosis (38.2%); and fibrosis F3/4 
      (71.2%). The following drugs were used: Telaprevir (66.2%) and PEG-IFN-alpha2a 
      (67.6%). Patients were naive (24.4%), relapsers (30.5%), partial responders 
      (14.8%) and null responders (30.3%). Overall, adverse events (AEs) occurred in 
      617 patients (73.9%) during the treatment. Anemia was the most frequent AE (52.9% 
      of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the 
      patients because of adverse events or virological failure (15%). Sustained 
      virological response was achieved in 62.7% of the cases, but was 43.8% in 
      cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple 
      therapy is safe but has moderate efficacy, especially for patients over 65 years 
      of age, with advanced fibrosis, non-responders to peginterferon + ribavirin.
FAU - Cleo Study Group
AU  - Cleo Study Group
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Ascione, Antonio
AU  - Ascione A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Adinolfi, Luigi Elio
AU  - Adinolfi LE
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Amoroso, Pietro
AU  - Amoroso P
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Andriulli, Angelo
AU  - Andriulli A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Armignacco, Orlando
AU  - Armignacco O
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Ascione, Tiziana
AU  - Ascione T
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Babudieri, Sergio
AU  - Babudieri S
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Barbarini, Giorgio
AU  - Barbarini G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Brogna, Michele
AU  - Brogna M
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Cesario, Francesco
AU  - Cesario F
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Citro, Vincenzo
AU  - Citro V
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Claar, Ernesto
AU  - Claar E
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Cozzolongo, Raffaele
AU  - Cozzolongo R
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - D'Adamo, Giuseppe
AU  - D'Adamo G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - D'Amico, Emilio
AU  - D'Amico E
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Dattolo, Pellegrino
AU  - Dattolo P
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Luca, Massimo
AU  - De Luca M
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Maria, Vincenzo
AU  - De Maria V
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Siena, Massimo
AU  - De Siena M
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Vita, Giuseppe
AU  - De Vita G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Di Giacomo, Antonio
AU  - Di Giacomo A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Marco, Rosanna
AU  - De Marco R
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Stefano, Giorgio
AU  - De Stefano G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - De Stefano, Giulio
AU  - De Stefano G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Di Salvo, Sebastiano
AU  - Di Salvo S
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Di Sarno, Raffaele
AU  - Di Sarno R
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Farella, Nunzia
AU  - Farella N
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Felicioni, Laura
AU  - Felicioni L
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Fimiani, Basilio
AU  - Fimiani B
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Fontanella, Luca
AU  - Fontanella L
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Foti, Giuseppe
AU  - Foti G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Furlan, Caterina
AU  - Furlan C
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Giancotti, Francesca
AU  - Giancotti F
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Giolitto, Giancarlo
AU  - Giolitto G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Gravina, Tiziana
AU  - Gravina T
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Guerrera, Barbara
AU  - Guerrera B
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Gulminetti, Roberto
AU  - Gulminetti R
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Iacobellis, Angelo
AU  - Iacobellis A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Imparato, Michele
AU  - Imparato M
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Iodice, Angelo
AU  - Iodice A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Iovinella, Vincenzo
AU  - Iovinella V
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Izzi, Antonio
AU  - Izzi A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Liberti, Alfonso
AU  - Liberti A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Leo, Pietro
AU  - Leo P
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Lettieri, Gennaro
AU  - Lettieri G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Luppino, Ileana
AU  - Luppino I
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Marrone, Aldo
AU  - Marrone A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Mazzoni, Ettore
AU  - Mazzoni E
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Messina, Vincenzo
AU  - Messina V
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Monarca, Roberto
AU  - Monarca R
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Narciso, Vincenzo
AU  - Narciso V
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Nosotti, Lorenzo
AU  - Nosotti L
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Pellicelli, Adriano Maria
AU  - Pellicelli AM
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Perrella, Alessandro
AU  - Perrella A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Piai, Guido
AU  - Piai G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Picardi, Antonio
AU  - Picardi A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Pierri, Paola
AU  - Pierri P
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Pietromatera, Grazia
AU  - Pietromatera G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Resta, Francesco
AU  - Resta F
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Rinaldi, Luca
AU  - Rinaldi L
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Romano, Mario
AU  - Romano M
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Rossini, Angelo
AU  - Rossini A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Russello, Maurizio
AU  - Russello M
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Russo, Grazia
AU  - Russo G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Sacco, Rodolfo
AU  - Sacco R
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Sangiovanni, Vincenzo
AU  - Sangiovanni V
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Schiano, Antonio
AU  - Schiano A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Sciambra, Antonio
AU  - Sciambra A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Scifo, Gaetano
AU  - Scifo G
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Simeone, Filomena
AU  - Simeone F
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Sullo, Annarita
AU  - Sullo A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Tarquini, Pierluigi
AU  - Tarquini P
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Tundo, Paolo
AU  - Tundo P
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
FAU - Vallone, Alfredo
AU  - Vallone A
AD  - Luigi Elio Adinolfi, Barbara Guerrera, Internal Medicine Unit, Second University 
      of Naples, 80125 Marcianise, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Hepatol
JT  - World journal of hepatology
JID - 101532469
PMC - PMC4976214
OTO - NOTNLM
OT  - Antiviral therapy
OT  - Boceprevir
OT  - Chronic hepatitis
OT  - Peg-interferon
OT  - Ribavirin
OT  - Telaprevir
EDAT- 2016/08/31 06:00
MHDA- 2016/08/31 06:01
PMCR- 2016/08/08
CRDT- 2016/08/31 06:00
PHST- 2016/02/23 00:00 [received]
PHST- 2016/06/23 00:00 [revised]
PHST- 2016/07/20 00:00 [accepted]
PHST- 2016/08/31 06:00 [entrez]
PHST- 2016/08/31 06:00 [pubmed]
PHST- 2016/08/31 06:01 [medline]
PHST- 2016/08/08 00:00 [pmc-release]
AID - 10.4254/wjh.v8.i22.949 [doi]
PST - ppublish
SO  - World J Hepatol. 2016 Aug 8;8(22):949-56. doi: 10.4254/wjh.v8.i22.949.