PMID- 27576457 OWN - NLM STAT- MEDLINE DCOM- 20170831 LR - 20181113 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 46 IP - 13 DP - 2016 Dec TI - Combined blood pool and extracellular contrast agents for pediatric and young adult cardiovascular magnetic resonance imaging. PG - 1822-1830 AB - BACKGROUND: A comprehensive cardiac magnetic resonance (cardiac MR) study including both late gadolinium enhancement (LGE) and MR angiography may be indicated for patients with a history of acquired or congenital heart disease. OBJECTIVE: To study the novel use of an extracellular agent for assessment of LGE combined with a blood pool contrast agent for detailed MR angiography evaluation to yield a comprehensive cardiac MR study in these patients. MATERIALS AND METHODS: We reviewed clinical cardiac MR studies utilizing extracellular and blood pool contrast agents and noted demographics, clinical data and adverse events. We rated LGE image quality and MR angiography image quality for each vascular segment and calculated inter-rater variability. We also quantified contrast-to-noise ratio (CNR). RESULTS: Thirty-three patients (mean age 13.9 +/- 3 years) received an extracellular contrast agent (10 gadobenate dimeglumine, 23 gadopentetate dimeglumine) and blood pool contrast agent (33 gadofosveset trisodium). No adverse events were reported. MRI indications included Kawasaki disease (8), cardiomyopathy and coronary anatomy (15), repaired congenital heart disease (8), and other (2). Mean LGE quality was 2.6 +/- 0.6 with 97% diagnostic imaging. LGE quality did not vary by type of contrast agent given (P = 0.07). Mean MR angiography quality score was 4.7 +/- 0.6, with high inter-rater agreement (k = 0.6-0.8, P < 0.002). MR angiography quality did not vary by type of contrast agent used (P = 0.6). CONCLUSION: Cardiac MR studies utilizing both extracellular and blood pool contrast agents are feasible and safe and provide excellent-quality LGE and MR angiography images. The use of two contrast agents allows for a comprehensive assessment of both myocardial viability and vascular anatomy during the same exam. FAU - Johnson, Joyce T AU - Johnson JT AD - Division of Pediatric Cardiology, Ann & Robert Lurie Children's Hospital of Chicago, 225 E. Chicago Ave., Box 21, Chicago, IL, 60611, USA. jtjohnson@luriechildrens.org. AD - Department of Pediatrics, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA. jtjohnson@luriechildrens.org. FAU - Robinson, Joshua D AU - Robinson JD AD - Division of Pediatric Cardiology, Ann & Robert Lurie Children's Hospital of Chicago, 225 E. Chicago Ave., Box 21, Chicago, IL, 60611, USA. AD - Department of Pediatrics, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA. AD - Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. FAU - Deng, Jie AU - Deng J AD - Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. AD - Department of Medical Imaging, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA. FAU - Rigsby, Cynthia K AU - Rigsby CK AD - Department of Pediatrics, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA. AD - Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. AD - Department of Medical Imaging, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20160830 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 15G12L5X8K (gadobenic acid) RN - 6HG8UB2MUY (Meglumine) RN - AU0V1LM3JT (Gadolinium) RN - K2I13DR72L (Gadolinium DTPA) RN - XM33Q67UVH (gadofosveset trisodium) SB - IM MH - Adolescent MH - Adult MH - Cardiovascular Diseases/*diagnostic imaging MH - Child MH - Child, Preschool MH - Contrast Media/*administration & dosage MH - Female MH - Gadolinium MH - Gadolinium DTPA MH - Heart Defects, Congenital/*diagnostic imaging MH - Humans MH - Image Enhancement/methods MH - Infant MH - Infant, Newborn MH - Magnetic Resonance Angiography/methods MH - Magnetic Resonance Imaging/methods MH - Male MH - Meglumine/analogs & derivatives MH - Organometallic Compounds MH - Retrospective Studies OTO - NOTNLM OT - Blood pool contrast agent OT - Cardiac magnetic resonance OT - Children OT - Heart OT - Late gadolinium enhancement OT - Magnetic resonance angiography EDAT- 2016/09/01 06:00 MHDA- 2017/09/01 06:00 CRDT- 2016/09/01 06:00 PHST- 2016/05/06 00:00 [received] PHST- 2016/08/12 00:00 [accepted] PHST- 2016/07/19 00:00 [revised] PHST- 2016/09/01 06:00 [pubmed] PHST- 2017/09/01 06:00 [medline] PHST- 2016/09/01 06:00 [entrez] AID - 10.1007/s00247-016-3694-8 [pii] AID - 10.1007/s00247-016-3694-8 [doi] PST - ppublish SO - Pediatr Radiol. 2016 Dec;46(13):1822-1830. doi: 10.1007/s00247-016-3694-8. Epub 2016 Aug 30.