PMID- 27576480
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20220330
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 170
IP  - 3
DP  - 2016
TI  - HLA and Delayed Drug-Induced Hypersensitivity.
PG  - 163-79
LID - 10.1159/000448217 [doi]
AB  - Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human 
      leukocyte antigen (HLA) alleles have been associated with delayed allergy 
      reactions following the administration of particular drugs. Examples are 
      HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 
      (allopurinol). Based on the identification of these associations, it may now be 
      possible to prevent certain allergy reactions that were, until recently, 
      considered unpredictable. In this review, we will focus on the pharmacogenetics 
      of the best-studied associations between specific HLA alleles and delayed allergy 
      reactions and describe the pathogenesis models proposed so far. Finally, we will 
      evaluate the genetic screening strategies available and discuss the clinical 
      relevance of a better understanding of the immunogenetics and mechanisms involved 
      in DDAR.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Sousa-Pinto, Bernardo
AU  - Sousa-Pinto B
AD  - Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculty of 
      Medicine, University of Porto, Porto, Portugal.
FAU - Correia, Claudia
AU  - Correia C
FAU - Gomes, Lidia
AU  - Gomes L
FAU - Gil-Mata, Sara
AU  - Gil-Mata S
FAU - Araujo, Luis
AU  - Araujo L
FAU - Correia, Osvaldo
AU  - Correia O
FAU - Delgado, Luis
AU  - Delgado L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160826
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Anticonvulsants)
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA Antigens)
RN  - 0 (Haptens)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Alleles
MH  - Anticonvulsants/adverse effects
MH  - Antiviral Agents/adverse effects
MH  - Disease Susceptibility
MH  - Drug Hypersensitivity/diagnosis/genetics/*immunology
MH  - Drug Hypersensitivity Syndrome/genetics/immunology
MH  - Female
MH  - Genetic Testing
MH  - HLA Antigens/genetics/*immunology
MH  - Haptens/immunology
MH  - Humans
MH  - Hypersensitivity, Delayed/diagnosis/genetics/*immunology
MH  - Male
MH  - Odds Ratio
MH  - Receptors, Immunologic/metabolism
MH  - Stevens-Johnson Syndrome/genetics/immunology
MH  - Virus Diseases/immunology/virology
MH  - Viruses/immunology
EDAT- 2016/09/01 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/09/01 06:00
PHST- 2016/01/05 00:00 [received]
PHST- 2016/09/01 06:00 [entrez]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - 000448217 [pii]
AID - 10.1159/000448217 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2016;170(3):163-79. doi: 10.1159/000448217. Epub 2016 
      Aug 26.