PMID- 27576738
OWN - NLM
STAT- MEDLINE
DCOM- 20171009
LR  - 20220311
IS  - 1742-2094 (Electronic)
IS  - 1742-2094 (Linking)
VI  - 13
IP  - 1
DP  - 2016 Aug 30
TI  - Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal 
      fluid after subarachnoid hemorrhage.
PG  - 217
LID - 10.1186/s12974-016-0675-7 [doi]
LID - 217
AB  - BACKGROUND: Interleukin-6 (IL-6), an inflammatory cytokine, plays important roles 
      in cerebrospinal fluid (CSF) after subarachnoid hemorrhage (SAH). Chemokines are 
      chemoattractant cytokines that regulate trafficking of monocytes/macrophages and 
      lymphocytes to sites of inflammation. However, no studies have been reported 
      regarding the temporal expression of these cytokines in CSF after SAH. FINDINGS: 
      The concentrations of IL-6, monocyte chemoattractant protein-1 (MCP-1), 
      interferon-gamma-inducible protein-10 (IP-10), and monokine induced by interferon-gamma 
      (MIG) in the CSF of ten patients with SAH were measured using ELISA kits over a 
      period of 14 days. All aneurysms were located in the anterior circulation. CSF 
      samples from patients with unruptured aneurysms were used as controls. The 
      concentration of IL-6 significantly increased during the acute stage of the 
      disease. The concentration of MCP-1 increased from days 1 to 5, peaking on day 3, 
      and decreased thereafter. The concentrations of IP-10 and MIG progressively 
      increased, peaked on day 5, and then gradually decreased. There were strong 
      correlations between the maximum levels of IL-6 and MCP-1 and IP-10 and MIG on 
      day 5. The maximum level of IL-6 was much higher in poor outcome patients than in 
      good outcome patients. CONCLUSIONS: The present investigation demonstrated that 
      increases in IL-6 levels may induce the expression of MCP-1 in CSF after SAH, 
      followed by increases in the expression of IP-10 and MIG. Dynamic changes in the 
      levels of these cytokines may induce inflammation and may be closely associated 
      with the development of delayed ischemic neurological deficits after SAH.
FAU - Niwa, Aichi
AU  - Niwa A
AD  - Department of Neurological Surgery, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Osuka, Koji
AU  - Osuka K
AUID- ORCID: 0000-0002-6301-3189
AD  - Department of Neurological Surgery, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan. kosuka@aichi-med-u.ac.jp.
FAU - Nakura, Takahiro
AU  - Nakura T
AD  - Department of Neurological Surgery, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Matsuo, Naoki
AU  - Matsuo N
AD  - Department of Neurological Surgery, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Watabe, Takeya
AU  - Watabe T
AD  - Department of Neurological Surgery, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
FAU - Takayasu, Masakazu
AU  - Takayasu M
AD  - Department of Neurological Surgery, Aichi Medical University, 1-1 Yazakokarimata, 
      Nagakute, Aichi, 480-1195, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160830
PL  - England
TA  - J Neuroinflammation
JT  - Journal of neuroinflammation
JID - 101222974
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL10 protein, human)
RN  - 0 (CXCL9 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/cerebrospinal fluid
MH  - Chemokine CCL2/*cerebrospinal fluid/genetics
MH  - Chemokine CXCL10/*cerebrospinal fluid/genetics
MH  - Chemokine CXCL9/*cerebrospinal fluid/genetics
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Interleukin-6/*cerebrospinal fluid/genetics
MH  - Male
MH  - Middle Aged
MH  - Subarachnoid Hemorrhage/*cerebrospinal fluid/*diagnosis/genetics
PMC - PMC5006407
OTO - NOTNLM
OT  - IP-10
OT  - Interleukin-6
OT  - MCP-1
OT  - MIG
OT  - Subarachnoid hemorrhage
EDAT- 2016/09/01 06:00
MHDA- 2017/10/11 06:00
PMCR- 2016/08/30
CRDT- 2016/09/01 06:00
PHST- 2016/02/17 00:00 [received]
PHST- 2016/08/17 00:00 [accepted]
PHST- 2016/09/01 06:00 [entrez]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2016/08/30 00:00 [pmc-release]
AID - 10.1186/s12974-016-0675-7 [pii]
AID - 675 [pii]
AID - 10.1186/s12974-016-0675-7 [doi]
PST - epublish
SO  - J Neuroinflammation. 2016 Aug 30;13(1):217. doi: 10.1186/s12974-016-0675-7.