PMID- 27577177
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20191210
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 71
IP  - 1
DP  - 2017 Jan
TI  - Pomegranate extract alleviates disease activity and some blood biomarkers of 
      inflammation and oxidative stress in Rheumatoid Arthritis patients.
PG  - 92-96
LID - 10.1038/ejcn.2016.151 [doi]
AB  - BACKGROUND/OBJECTIVES: Since the main characteristics of Rheumatoid Arthritis 
      (RA) are joint dysfunction caused by inflammation and serious pain, 
      anti-inflammatory agents may alleviate the clinical symptoms in RA. Pomegranate 
      juice is rich in polyphenolic compounds that possess antioxidant and 
      anti-inflammatory activities. This study aimed to determine the beneficial 
      effects of pomegranate extract (POMx) in RA patients. SUBJECTS/METHODS: A total 
      of 55 RA patients were enrolled and randomly allocated to an intervention group 
      (n=30) or a control group (n=25). The intervention group received 2 capsules of 
      250 mg POMx and the control group 2 capsules of 250 mg cellulose per day for 8 
      weeks. At the beginning of the study and after 8 weeks, Health Assessment 
      Questionnaire (HAQ) and Disease Activity Score (DAS) 28 were completed and serum 
      concentrations of C-reactive protein (CRP), matrix metalloproteinases 3 (MMP3), 
      malondialdehyde (MDA), glutathione peroxidase (GPx) and erythrocyte sedimentation 
      rate (ESR) were analyzed using standard methods and compared between the two 
      groups. RESULTS: Compared with the placebo group, POMx supplement significantly 
      reduced the score of DAS28 (P<0.001) which could be related to the decrease in 
      swollen (P<0.001) and tender joints (P=0.001) count, pain intensity (P=0.003) and 
      ESR levels (P= 0.03). POMx consumption also decreased HAQ score (P=0.007) and 
      morning stiffness (P=0.04) and increased GPx concentrations (P<0.001). There were 
      no differences in the change in mean MMP3, CRP and MDA levels between two groups. 
      CONCLUSIONS: POMx alleviates disease activity and improves some blood biomarkers 
      of inflammation and oxidative stress in RA patients.
FAU - Ghavipour, M
AU  - Ghavipour M
AD  - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz 
      University of Medical Science, Shiraz, Iran.
FAU - Sotoudeh, G
AU  - Sotoudeh G
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Tavakoli, E
AU  - Tavakoli E
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz 
      University of Medical Science, Shiraz, Iran.
FAU - Mowla, K
AU  - Mowla K
AD  - Department of Rheumatology, Ahwaz University of Medical Science, Ahwaz, Iran.
FAU - Hasanzadeh, J
AU  - Hasanzadeh J
AD  - Department of Epidemiology, School of Health, Shiraz University of Medical 
      Science, Shiraz, Iran.
FAU - Mazloom, Z
AU  - Mazloom Z
AD  - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz 
      University of Medical Science, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160831
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Plant Extracts)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Antioxidants/*administration & dosage
MH  - Arthritis, Rheumatoid/blood/*drug therapy
MH  - Biomarkers/blood
MH  - Blood Sedimentation/drug effects
MH  - C-Reactive Protein/analysis
MH  - Double-Blind Method
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Inflammation
MH  - Lythraceae/*chemistry
MH  - Male
MH  - Malondialdehyde/blood
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Phytotherapy/*methods
MH  - Plant Extracts/*administration & dosage
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2016/09/01 06:00
MHDA- 2018/01/13 06:00
CRDT- 2016/09/01 06:00
PHST- 2016/02/08 00:00 [received]
PHST- 2016/06/17 00:00 [revised]
PHST- 2016/07/06 00:00 [accepted]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/09/01 06:00 [entrez]
AID - ejcn2016151 [pii]
AID - 10.1038/ejcn.2016.151 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2017 Jan;71(1):92-96. doi: 10.1038/ejcn.2016.151. Epub 2016 Aug 
      31.