PMID- 27577225
OWN - NLM
STAT- MEDLINE
DCOM- 20170104
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 33
IP  - 5
DP  - 2016 Oct
TI  - [Analysis of HPA1-16 and HLA-A, B gene polymorphisms among ethnic Han population 
      from Shandong].
PG  - 690-3
LID - 10.3760/cma.j.issn.1003-9406.2016.05.025 [doi]
AB  - OBJECTIVE: To study the polymorphisms of human platelet antigen (HPA) 1-16 and 
      human leukocyte antigen (HLA)-A and -B loci among ethnic Han population from 
      Shandong. METHODS: A total of 588 samples from platelet donors were genotyped for 
      the above loci with sequence-specific primer PCR and sequence-specific 
      oligonucleotide probe PCR. RESULTS: The frequencies of HPA-la, -1b, HPA-2a, -2b, 
      HPA-3a, -3b, HPA-4a, -4b, HPA-5a, -5b, HPA-6a, -6b, HPA-15a, -15b were 0.9974, 
      0.0026, 0.9456, 0.0544, 0.5417, 0.4583, 0.9983, 0.0017, 0.9889, 0.0111, 0.9903, 
      0.0097, 0.5434 and 0.4583, respectively. The HPA-7-14 and HPA-16 showed no 
      heterozygosity as the b allele was not detected in such loci. The most common 
      genotypic combination for HPA was HPA-(1,4,7-14,16,17) aa-2aa-3ab-5aa -6aa-15ab 
      (0.1820). HLA-A2 (0.3070) and HLA-B13 (0.1361) demonstrated the highest 
      frequencies at their respective loci. CONCLUSION: The HPA and HLA loci are highly 
      polymorphic among ethnic Hans from Shandong. The distribution of HPA 
      polymorphisms also shows a great ethnic and territorial difference. It is 
      important to construct regional database for the genotypes of HPA and HLA loci 
      for platelet donors.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - HLA Laboratory, Blood Center of Shandong Province, Jinan, Shandong 250014, China. 
      Email: sdhla@aliyun.com.
FAU - Yu, Yuan
AU  - Yu Y
FAU - Qiao, Wenben
AU  - Qiao W
FAU - Liu, Yan
AU  - Liu Y
FAU - Zhou, Juan
AU  - Zhou J
FAU - Xu, Jianhong
AU  - Xu J
FAU - Fan, Bing
AU  - Fan B
FAU - Jiang, Liyue
AU  - Jiang L
FAU - Liang, Wenhua
AU  - Liang W
FAU - Zhu, Chuanfu
AU  - Zhu C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Antigens, Human Platelet/*genetics
MH  - Asian People/genetics/statistics & numerical data
MH  - Blood Donors
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2016/09/01 06:00
MHDA- 2017/01/05 06:00
CRDT- 2016/09/01 06:00
PHST- 2016/09/01 06:00 [entrez]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2017/01/05 06:00 [medline]
AID - 940633146 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2016.05.025 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Oct;33(5):690-3. doi: 
      10.3760/cma.j.issn.1003-9406.2016.05.025.