PMID- 27578176
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20220410
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Linking)
VI  - 143
IP  - 17
DP  - 2016 Sep 1
TI  - Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in 
      pluripotency and cell fate determination.
PG  - 3050-60
LID - 10.1242/dev.137075 [doi]
AB  - Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and 
      mammalian target of rapamycin (mTOR) constitute the core components of the 
      PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and 
      metabolism. Although these functions are well-defined in the context of 
      tumorigenesis, recent studies - in particular those using pluripotent stem cells 
      - have highlighted the importance of this pathway to development and cellular 
      differentiation. Here, we review the recent in vitro and in vivo evidence for the 
      role PI3K/AKT/mTOR signalling plays in the control of pluripotency and 
      differentiation, with a particular focus on the molecular mechanisms underlying 
      these functions.
CI  - (c) 2016. Published by The Company of Biologists Ltd.
FAU - Yu, Jason S L
AU  - Yu JS
AUID- ORCID: 0000-0001-5203-3603
AD  - Institute of Reproductive and Developmental Biology, Department of Surgery and 
      Cancer, Imperial College London, Du Cane Road, London W12 0NN, UK.
FAU - Cui, Wei
AU  - Cui W
AUID- ORCID: 0000-0003-2019-380X
AD  - Institute of Reproductive and Developmental Biology, Department of Surgery and 
      Cancer, Imperial College London, Du Cane Road, London W12 0NN, UK 
      wei.cui@imperial.ac.uk.
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/genetics/*physiology
MH  - Cell Survival/genetics/*physiology
MH  - Humans
MH  - Phosphatidylinositol 3-Kinases/genetics/*metabolism
MH  - Pluripotent Stem Cells/metabolism
MH  - Proto-Oncogene Proteins c-akt/genetics/*metabolism
MH  - Signal Transduction/genetics/physiology
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
OTO - NOTNLM
OT  - AKT
OT  - Metabolism
OT  - PI3K
OT  - Pluripotency
OT  - Proliferation and differentiation
OT  - mTOR
EDAT- 2016/09/01 06:00
MHDA- 2017/09/07 06:00
CRDT- 2016/09/01 06:00
PHST- 2016/09/01 06:00 [entrez]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
AID - 143/17/3050 [pii]
AID - 10.1242/dev.137075 [doi]
PST - ppublish
SO  - Development. 2016 Sep 1;143(17):3050-60. doi: 10.1242/dev.137075.