PMID- 27578978
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160831
LR  - 20220318
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 12
DP  - 2016
TI  - Mean platelet volume in bipolar disorder: the search for an ideal biomarker.
PG  - 2057-62
LID - 10.2147/NDT.S112374 [doi]
AB  - BACKGROUND: The pathophysiology of bipolar disorder (BD) remains a mystery. In 
      this context, interest in the role of the immune and inflammatory systems in BD 
      has been increasing. We aimed to compare the routine hemogram values of BD 
      patients with those of the participants in the healthy control group, to assess 
      the inflammation levels of the two groups. Mean platelet volume (MPV) can be 
      obtained as routine hemogram parameters and may aid in the detection of systemic 
      inflammation. SUBJECTS AND METHODS: This study was conducted with BD (manic 
      episode) inpatients (n=132) and healthy controls (n=135). Abnormally distributed 
      variables (ie, neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio 
      [PLR], neutrophils, lymphocytes, hemoglobin, hematocrit [HCT], mean corpuscular 
      volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin 
      concentration [MCHC], red cell distribution width [RDW], MPV, and plateletcrit 
      [PCT]) were compared using the Mann-Whitney U-test. Student's t-test was used to 
      compare the mean ages and white blood cell, red blood cell, and platelet counts 
      of the patients with BD against those of the participants in the control group. 
      RESULTS: The comparisons revealed that while the mean WBC and the median NLR, 
      PLR, neutrophil, lymphocyte, MPV, and PCT values were significantly higher in the 
      patients with BD (P<0.05), the median hemoglobin, RBC, HCT, and MCHC values were 
      significantly higher in the control group (P<0.05). CONCLUSION: Comparisons of 
      hemogram values of patients with BD against those of the healthy control group 
      revealed that inflammatory cells (absolute neutrophil count, platelet count, PCT, 
      and MPV) and ratios (NLR, PLR) seem to be altered during manic episodes. These 
      findings support the hypothesis that inflammatory activation occurs in BD during 
      manic episodes. In addition to NLR and PLR, MPV may be useful in the detection of 
      this activation. The most significant limitation in the study is that smokers 
      were not excluded in both groups. The development of new preventive and 
      therapeutic options can be facilitated through the understanding of this 
      mechanism because through this mechanism, inflammation may pathologically affect 
      brain function, as well as inducing and/or perpetuating BD.
FAU - Mert, Derya Guliz
AU  - Mert DG
AD  - Department of Psychiatry.
FAU - Terzi, Hatice
AU  - Terzi H
AD  - Department of Hematology, Faculty of Medicine, Cumhuriyet University, Sivas, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160816
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC4998027
OTO - NOTNLM
OT  - bipolar disorder
OT  - inflammation
OT  - mean platelet volume
EDAT- 2016/09/01 06:00
MHDA- 2016/09/01 06:01
PMCR- 2016/08/16
CRDT- 2016/09/01 06:00
PHST- 2016/09/01 06:00 [entrez]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2016/09/01 06:01 [medline]
PHST- 2016/08/16 00:00 [pmc-release]
AID - ndt-12-2057 [pii]
AID - 10.2147/NDT.S112374 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2016 Aug 16;12:2057-62. doi: 10.2147/NDT.S112374. 
      eCollection 2016.