PMID- 27579273
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160831
LR  - 20200929
IS  - 2228-7914 (Print)
IS  - 2252-0724 (Electronic)
IS  - 2228-7914 (Linking)
VI  - 5
IP  - 2
DP  - 2016 May
TI  - The Healing Effect of Bone Marrow-Derived Stem Cells in Knee Osteoarthritis: A 
      Case Report.
PG  - 168-74
AB  - Osteoarthritis (OA) is a prevalent chronic disease impacting on quality of life 
      and has societal and economical burden increasing with age. Yet, no confirmed 
      pharmacological, biological or surgical therapy could prevent the progressive 
      destruction of OA joint. Mesenchymal stem cells (MSCs) with immunosuppressive 
      activities emerged a potential therapy. We describe a magnetic resonance images 
      (MRI) approved 47 years old nomad female suffering from a severe right knee OA. 
      After intra-articular injection of 36x10(6) passage 2 of bone marrow-derived stem 
      cells (BMSCs), the patient's functional status of the knee, the number of stairs 
      she could climb, the pain on visual analog scale (VAS) and walking distance 
      improved after two months post-transplantation. MRI revealed an extension of the 
      repaired tissue over subchondral bone. So as MSC transplantation is a simple 
      technique, resulted into pain relief, minimized donor-site morbidity, provided a 
      better quality of life, significantly improved cartilage quality with no need to 
      hospitalization or surgery, cell transplantation can be considered as a reliable 
      alternative treatment for chronic knee OA. Therefore these findings can be added 
      to the literature on using BMSCs for treatment of OA.
FAU - Mehrabani, Davood
AU  - Mehrabani D
AD  - Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran;; Department of Regenerative Medicine, University of 
      Manitoba, Winnipeg, MB, Canada;
FAU - Mojtahed Jaberi, Fereidoon
AU  - Mojtahed Jaberi F
AD  - Bone and Joint Diseases Research Center & Department of Orthopedic Surgery, 
      Shiraz University of Medical Sciences, Shiraz, Iran;
FAU - Zakerinia, Maryam
AU  - Zakerinia M
AD  - Hematology Research Center & Department of Internal Medicine, Shiraz University 
      of Medical Sciences, Shiraz, Iran;
FAU - Hadianfard, Mohammad Javad
AU  - Hadianfard MJ
AD  - Department of Physical Medicine and Rehabilitation, Shiraz University of Medical 
      Sciences, Shiraz, Iran;
FAU - Jalli, Reza
AU  - Jalli R
AD  - Medical Imaging Research Center & Department of Radiology, Shiraz University of 
      Medical Sciences, Shiraz, Iran.
FAU - Tanideh, Nader
AU  - Tanideh N
AD  - Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran;
FAU - Zare, Shahrokh
AU  - Zare S
AD  - Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical 
      Sciences, Shiraz, Iran;
LA  - eng
PT  - Case Reports
PL  - Iran
TA  - World J Plast Surg
JT  - World journal of plastic surgery
JID - 101639130
PMC - PMC5003953
OTO - NOTNLM
OT  - Bone Marrow
OT  - Knee
OT  - Mesenchymal Stem Cell
OT  - Osteoarthritis
OT  - Transplantation
EDAT- 2016/09/01 06:00
MHDA- 2016/09/01 06:01
PMCR- 2016/05/01
CRDT- 2016/09/01 06:00
PHST- 2016/09/01 06:00 [entrez]
PHST- 2016/09/01 06:00 [pubmed]
PHST- 2016/09/01 06:01 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - wjps-5-168 [pii]
PST - ppublish
SO  - World J Plast Surg. 2016 May;5(2):168-74.