PMID- 27580643
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 47
IP  - 8
DP  - 2017 Jul
TI  - HLA-DQ gene polymorphisms are associated with hepatocellular carcinoma and 
      hepatitis B surface antigen in chronic hepatitis B virus infection.
PG  - 755-766
LID - 10.1111/hepr.12812 [doi]
AB  - AIM: Genome-wide association studies have revealed that single nucleotide 
      polymorphism (SNP) of human leukocyte antigen (HLA)-DQ is associated with the 
      clearance of hepatitis B surface antigen (HBsAg) in acute hepatitis B virus (HBV) 
      infection. We examined the effects of SNPs on the development of hepatocellular 
      carcinoma (HCC) and markers of HBV in chronic HBV infection. METHODS: The SNPs of 
      HLA-DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV 
      infection. RESULTS: In 224 hepatitis B e antigen (HBeAg)-negative patients, those 
      with rs2856718 genotype AG + GG had significantly lower hepatitis B core-related 
      antigen levels (P = 0.0184), less frequent treatment with nucleotide/nucleoside 
      analogs (NAs) (P = 0.0433), and less frequent HCC development (P = 0.0256) than 
      those with genotype AA. Multivariate analysis selected age (P = 0.0460), platelet 
      count (P = 0.0481), gamma-glutamyl transpeptidase (P = 0.0030), and 
      nucleotide/nucleoside analog treatment (P = 0.0003) as factors independently 
      associated with HCC development. HBeAg-negative patients with rs7453920 genotype 
      GG had significantly lower HBsAg levels (P < 0.0001), a higher prevalence of HBV 
      genotype C (P = 0.0063), and a lower prevalence of the wild-type basal core 
      promoter region (P = 0.0045) than those with genotype AA + AG. Multivariate 
      analysis selected age (P < 0.0001), platelet count (P = 0.0021), HBV DNA levels 
      (P = 0.0314), wild type of precore region (P = 0.0015), and rs7453920 
      (P < 0.0001) as factors independently associated with HBsAg levels. CONCLUSION: 
      This study revealed an association between rs2856718 and HCC development and an 
      association between rs7453920 and HBsAg levels.
CI  - (c) 2016 The Japan Society of Hepatology.
FAU - Ochi, Yuka
AU  - Ochi Y
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Hashimoto, Senju
AU  - Hashimoto S
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Kawabe, Naoto
AU  - Kawabe N
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Murao, Michihito
AU  - Murao M
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Nakano, Takuji
AU  - Nakano T
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Kan, Toshiki
AU  - Kan T
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Nakaoka, Kazunori
AU  - Nakaoka K
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Ohki, Masashi
AU  - Ohki M
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Kurashita, Takamitsu
AU  - Kurashita T
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Takamura, Tomoki
AU  - Takamura T
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Nomura, Sayuri
AU  - Nomura S
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Nishikawa, Toru
AU  - Nishikawa T
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
FAU - Fukui, Aiko
AU  - Fukui A
AD  - Department of Clinical Pharmacy Practice and Health Care Management, Faculty of 
      Pharmacy, Meijo University, Nagoya, Japan.
FAU - Osakabe, Keisuke
AU  - Osakabe K
AD  - Faculty of Medical Technology, School of Health Sciences, Fujita Health 
      University, Toyoake, Japan.
FAU - Ichino, Naohiro
AU  - Ichino N
AD  - Faculty of Medical Technology, School of Health Sciences, Fujita Health 
      University, Toyoake, Japan.
FAU - Yoshioka, Kentaro
AU  - Yoshioka K
AD  - Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health 
      University, Toyoake, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161011
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
OTO - NOTNLM
OT  - HBcrAg
OT  - HBeAg
OT  - HBsAg
OT  - HLA-DQ
OT  - hepatitis B virus
OT  - hepatocellular carcinoma
EDAT- 2016/09/02 06:00
MHDA- 2016/09/02 06:01
CRDT- 2016/09/02 06:00
PHST- 2016/07/03 00:00 [received]
PHST- 2016/08/14 00:00 [revised]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/09/02 06:00 [pubmed]
PHST- 2016/09/02 06:01 [medline]
PHST- 2016/09/02 06:00 [entrez]
AID - 10.1111/hepr.12812 [doi]
PST - ppublish
SO  - Hepatol Res. 2017 Jul;47(8):755-766. doi: 10.1111/hepr.12812. Epub 2016 Oct 11.