PMID- 27581838
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20181113
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 15
IP  - 1
DP  - 2016 Aug 31
TI  - Plasma phospholipid transfer protein activity is inversely associated with 
      betaine in diabetic and non-diabetic subjects.
PG  - 143
LID - 10.1186/s12944-016-0313-5 [doi]
LID - 143
AB  - BACKGROUND: The choline metabolite, betaine, plays a role in lipid metabolism, 
      and may predict the development of cardiovascular disease and type 2 diabetes 
      mellitus (T2DM). Phospholipid transfer protein (PLTP) and lecithin:cholesterol 
      acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the 
      possibility that there is an intricate relationship of these protein factors with 
      choline metabolism. Here we determined the relationships of PLTP and LCAT 
      activity with betaine in subjects with and without T2DM. METHODS: Plasma betaine 
      (nuclear magnetic resonance spectroscopy), PLTP activity (liposome-vesicle HDL 
      system), LCAT activity (exogenous substrate assay) and (apo)lipoproteins were 
      measured in 65 type 2 diabetic (T2DM) and in 55 non-diabetic subjects. RESULTS: 
      PLTP and LCAT activity were elevated in T2DM (p < 0.05), whereas the difference 
      in betaine was not significant. In age-, sex- and diabetes status-controlled 
      correlation analysis, betaine was inversely correlated with triglycerides and 
      positively with HDL cholesterol (p < 0.05 to 0.01). PLTP and LCAT activity were 
      positively correlated with triglycerides and inversely with HDL cholesterol 
      (p < 0.05 to 0.001). PLTP (r = -0.245, p = 0.006) and LCAT activity (r = -0.195, 
      p = 0.035) were correlated inversely with betaine. The inverse association of 
      PLTP activity with betaine remained significant after additional adjustment for 
      body mass index and lipoprotein variables (beta = -0.179, p = 0.034), whereas its 
      association with LCAT activity lost significance (beta = -0.056, p = 0.44). 
      CONCLUSIONS: Betaine may influence lipoprotein metabolism via an effect on PLTP 
      activity.
FAU - Dullaart, R P F
AU  - Dullaart RP
AD  - Department of Endocrinology, University Medical Center Groningen, University of 
      Groningen, P.O. Box 30.001, Groningen, 9700 RB, The Netherlands. 
      r.p.f.dullaart@umcg.nl.
FAU - Garcia, Erwin
AU  - Garcia E
AD  - LipoScience, Laboratory Corporation of America(R) Holdings, Raleigh, NC, USA.
FAU - Jeyarajah, Elias
AU  - Jeyarajah E
AD  - LipoScience, Laboratory Corporation of America(R) Holdings, Raleigh, NC, USA.
FAU - Gruppen, Eke G
AU  - Gruppen EG
AD  - Departments of Endocrinology and Nephrology, University of Groningen and 
      University Medical Center Groningen, Groningen, The Netherlands.
FAU - Connelly, Margery A
AU  - Connelly MA
AD  - LipoScience, Laboratory Corporation of America(R) Holdings, Raleigh, NC, USA.
LA  - eng
PT  - Journal Article
DEP - 20160831
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Phospholipid Transfer Proteins)
RN  - 0 (Triglycerides)
RN  - 3SCV180C9W (Betaine)
RN  - EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Betaine/*blood
MH  - Blood Glucose/analysis
MH  - Cholesterol, HDL/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phosphatidylcholine-Sterol O-Acyltransferase/blood
MH  - Phospholipid Transfer Proteins/*blood
MH  - Triglycerides/blood
PMC - PMC5007837
OTO - NOTNLM
OT  - Betaine
OT  - Lecithin:cholesterol acyltransferase
OT  - Lipoproteins
OT  - Phospholipid transfer protein
OT  - Type 2 diabetes mellitus
EDAT- 2016/09/02 06:00
MHDA- 2017/03/28 06:00
PMCR- 2016/08/31
CRDT- 2016/09/02 06:00
PHST- 2016/07/15 00:00 [received]
PHST- 2016/08/23 00:00 [accepted]
PHST- 2016/09/02 06:00 [entrez]
PHST- 2016/09/02 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
PHST- 2016/08/31 00:00 [pmc-release]
AID - 10.1186/s12944-016-0313-5 [pii]
AID - 313 [pii]
AID - 10.1186/s12944-016-0313-5 [doi]
PST - epublish
SO  - Lipids Health Dis. 2016 Aug 31;15(1):143. doi: 10.1186/s12944-016-0313-5.