PMID- 27582780
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160901
LR  - 20200929
IS  - 1744-859X (Print)
IS  - 1744-859X (Electronic)
IS  - 1744-859X (Linking)
VI  - 15
IP  - 1
DP  - 2016
TI  - A prospective hospital study of alcohol use disorders, comorbid psychiatric 
      conditions and withdrawal prognosis.
PG  - 22
LID - 10.1186/s12991-016-0111-5 [doi]
LID - 22
AB  - BACKGROUND: The objective of this study was to describe the profile and alcoholic 
      status of a population with alcohol use disorders (AUD) requesting help from a 
      psychiatric hospital to stop drinking, as well as their clinical outcome and care 
      consumption over the 2 years following the request. METHODS: The visits were 
      conducted at baseline (M0) and at 6, 12, 18 and 24 months (M6, M12, M18, M24). 
      Demographic, clinical and psychometric data [Beck Depression Inventory (BDI), 
      AUDIT questionnaire, Global Assessment of Functioning (GAF) scale], and 
      information regarding the use of psychiatric care and therapeutics were 
      collected. RESULTS: The 330 subjects included were mostly male, aged 
      45.2 +/- 10.2 years with an employment rate of 55.4 %, living alone (69.1 %), with 
      a psychiatric comorbidity (60.9 %), especially depressive, and with few somatic 
      complications. Their global functioning was poor (GAF score 49.14 +/- 15.6), and 
      less than 10 % were addicted to another substance. The abstinence rate at 
      24 months was 41.4 %, but only 23 % (20) abstained continuously between M0 and 
      M24, and 66.7 % (58) intermittently. The likelihood of abstinence at M24 was 
      greater for females aged over 60 years. The BDI score decreased significantly 
      between M0 and M24. In all, 56.2 % of the participants were re-hospitalized after 
      weaning, but were not integrated in long-term medical care. CONCLUSIONS: 
      Abstinence after alcohol withdrawal fluctuated over time indicating the need for 
      long-term support. The treatment of AUD should not target total, continuous 
      abstinence. Prognostic profiles combining socio-demographic, clinical and 
      biological indicators must be established.
FAU - Nubukpo, Philippe
AU  - Nubukpo P
AD  - Pole Addictologie, Centre Hospitalier Esquirol, 15 rue du Dr Marcland, 87025 
      Limoges, France ; Departement de Recherche et Developpement (DRD), Centre 
      Hospitalier Esquirol, 87025 Limoges, France ; Faculte de Medecine, 
      UMR/INSERM1094, 2 rue du Dr Marcland, 87025 Limoges, France.
FAU - Girard, Murielle
AU  - Girard M
AD  - Departement de Recherche et Developpement (DRD), Centre Hospitalier Esquirol, 
      87025 Limoges, France.
FAU - Sengelen, Jean-Marie
AU  - Sengelen JM
AD  - Pole de Psychiatrie Infanto Juvenile, Centre Hospitalier Esquirol, 87025 Limoges, 
      France.
FAU - Bonnefond, Sophie
AU  - Bonnefond S
AD  - Pole de Psychiatrie Adulte, Centre Hospitalier Esquirol, 87025 Limoges, France.
FAU - Varnoux, Aurelien
AU  - Varnoux A
AD  - Pole de Psychiatrie Adulte, Centre Hospitalier Esquirol, 87025 Limoges, France.
FAU - Marin, Benoit
AU  - Marin B
AD  - Faculte de Medecine, UMR/INSERM1094, 2 rue du Dr Marcland, 87025 Limoges, France.
FAU - Malauzat, Dominique
AU  - Malauzat D
AD  - Departement de Recherche et Developpement (DRD), Centre Hospitalier Esquirol, 
      87025 Limoges, France.
LA  - eng
PT  - Journal Article
DEP - 20160831
PL  - England
TA  - Ann Gen Psychiatry
JT  - Annals of general psychiatry
JID - 101236515
PMC - PMC5006587
OTO - NOTNLM
OT  - Abstinence
OT  - Alcohol
OT  - Comorbidity
OT  - Psychiatric care
OT  - Psychiatry
OT  - Withdrawal
EDAT- 2016/09/02 06:00
MHDA- 2016/09/02 06:01
PMCR- 2016/08/31
CRDT- 2016/09/02 06:00
PHST- 2015/11/30 00:00 [received]
PHST- 2016/08/21 00:00 [accepted]
PHST- 2016/09/02 06:00 [entrez]
PHST- 2016/09/02 06:00 [pubmed]
PHST- 2016/09/02 06:01 [medline]
PHST- 2016/08/31 00:00 [pmc-release]
AID - 111 [pii]
AID - 10.1186/s12991-016-0111-5 [doi]
PST - epublish
SO  - Ann Gen Psychiatry. 2016 Aug 31;15(1):22. doi: 10.1186/s12991-016-0111-5. 
      eCollection 2016.