PMID- 27583850
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20220321
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 35
DP  - 2016 Aug
TI  - Association between tumor necrosis factor-alpha G-308A polymorphism and dental 
      peri-implant disease risk: A meta-analysis.
PG  - e4425
LID - 10.1097/MD.0000000000004425 [doi]
LID - e4425
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a potent immune-inflammatory 
      mediator involved in the regulation of bone resorption. The single nucleotide 
      polymorphism G-308A in the TNF-alpha gene increases the level of this cytokine. This 
      phenomenon is also related to several diseases. Although the association between 
      TNF-alpha (G-308A) polymorphism and dental peri-implant disease has been 
      investigated, results have remained controversial. Hence, we performed this 
      meta-analysis to provide a comprehensive and systematic conclusion on this topic. 
      METHODS: We performed a systematic literature search in PubMed, Embase, ISI Web 
      of Science, Cochrane Library, and Chinese National Knowledge Infrastructure until 
      July 2015. A fixed-effect model was established to calculate pooled odds ratios 
      (ORs) and 95% confidence intervals (CIs). The calculated values were then used to 
      assess the strength of the association between the TNF-alpha (G-308A) polymorphism 
      and the dental peri-implant disease risk. The heterogeneity between included 
      studies was evaluated with Cochran Q and I statistics. Interstudy publication 
      bias was investigated with a funnel plot. RESULTS: Six eligible studies were 
      included in this meta-analysis. The pooled ORs did not reveal a significant 
      relationship between the TNF-alpha (G-308A) polymorphism and the disease 
      susceptibility. Subgroup analyses in terms of ethnicity and disease type yielded 
      similar results. CONCLUSION: Our meta-analysis revealed that TNF-alpha (G-308A) 
      polymorphism was not significantly associated with the risk of dental 
      peri-implant disease. However, further studies with large sample sizes should be 
      performed to verify these results.
FAU - Mo, Yuan-Yuan
AU  - Mo YY
AD  - Department of Stomatology, Daping Hospital and Research Institute of Surgery, 
      Third Military Medical University, Chongqing Center for Evidence-Based and 
      Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Zeng, Xian-Tao
AU  - Zeng XT
FAU - Weng, Hong
AU  - Weng H
FAU - Cen, Ying
AU  - Cen Y
FAU - Zhao, Qian
AU  - Zhao Q
FAU - Wen, Xiujie
AU  - Wen X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Dental Implants)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Dental Implantation, Endosseous/adverse effects
MH  - Dental Implants/*adverse effects
MH  - Dental Restoration Failure
MH  - Humans
MH  - Peri-Implantitis/etiology/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC5008534
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/09/02 06:00
MHDA- 2017/02/10 06:00
PMCR- 2016/09/02
CRDT- 2016/09/02 06:00
PHST- 2016/09/02 06:00 [entrez]
PHST- 2016/09/02 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
PHST- 2016/09/02 00:00 [pmc-release]
AID - 00005792-201608300-00010 [pii]
AID - 10.1097/MD.0000000000004425 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Aug;95(35):e4425. doi: 10.1097/MD.0000000000004425.