PMID- 27584557
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160902
LR  - 20200929
IS  - 1523-7834 (Print)
IS  - 1523-7834 (Linking)
VI  - 42
IP  - 2
DP  - 2016
TI  - CML in Chronic Phase with Novel Secondary Cytogenetic Abnormalities: A Case 
      Report.
PG  - 57-9
AB  - The clonal evolution in t(9;22)-positive Chronic Myelocytic Leukemia (CML) 
      patients is well established. Four major changes occur in more than 70% of 
      patients: +8, i(17q), +19, and an extra Philadelphia chromosome. Here, we present 
      a case with CML-Chronic phase (CML-CP) and novel t(9;13)(q34;q12~13) in addition 
      to t(9;22)(q34;q11.2). Fluorescence in situ hybridization (FISH) using dual color 
      dual fusion probe analysis on interphase and metaphase cells confirmed the 
      t(9;13)(q34;q12~13) as clonal evolution and secondary event to Philadelphia 
      chromosome. This suggests minor route additional chromosomal aberrations which 
      might affect prognosis. Further studies are required to ascertain the expression 
      of genes that play a role in CML-blast crisis in order to to explore its 
      therapeutic significance and prognostic value.
FAU - Patel, Hiral S
AU  - Patel HS
AD  - The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, India.
FAU - Brahmbhatt, Manisha M
AU  - Brahmbhatt MM
AD  - The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, India.
FAU - Trivedi, Pina J
AU  - Trivedi PJ
AD  - The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, India.
FAU - Patel, Dharmesh M
AU  - Patel DM
AD  - The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, India.
FAU - Sugandhi, Ankita A
AU  - Sugandhi AA
AD  - The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, India.
FAU - Patel, Binita V
AU  - Patel BV
AD  - The Gujarat cancer and Research Institute, Asarwa, Ahmedabad, India.
FAU - Patel, Prabhudas S
AU  - Patel PS
AD  - The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Assoc Genet Technol
JT  - Journal of the Association of Genetic Technologists
JID - 9807282
EDAT- 2016/09/02 06:00
MHDA- 2016/09/02 06:01
CRDT- 2016/09/02 06:00
PHST- 2016/09/02 06:00 [entrez]
PHST- 2016/09/02 06:00 [pubmed]
PHST- 2016/09/02 06:01 [medline]
PST - ppublish
SO  - J Assoc Genet Technol. 2016;42(2):57-9.