PMID- 27585642
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20181202
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 27
IP  - 3
DP  - 2017 May
TI  - Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients 
      with rheumatoid arthritis.
PG  - 441-447
LID - 10.1080/14397595.2016.1218595 [doi]
AB  - INTRODUCTION: Rheumatoid arthritis (RA) is an autoimmune disease that causes 
      chronic inflammation of the joints. Recent evidence indicated the epigenetic 
      changes may contribute to the pathogenesis of RA. METHOD: To understand the 
      extent and nature of dysregulated DNA methylation in RA CD4T cells, we performed 
      a genome-wide DNA methylation study in CD4 + T cells in 12 RA patients compared 
      to 12 matched normal healthy controls. Cytosine methylation status was quantified 
      with Illumina methylation 450K microarray. RESULT: The DNA methylation profiling 
      showed 383 hyper- and 785 hypo-methylated genes in the CD4 + T cells of the RA 
      patients (p < 3.4 x 10(-7)). Gene ontology analysis indicated transcript 
      alternative splicing and protein modification mediated by DNA methylation might 
      play an important role in the pathogenesis of RA. In addition, the result showed 
      that human leukocyte antigen (HLA) region including HLA-DRB6, HLA-DQA1 and HLA-E 
      was frequently hypomethylated, but HLA-DQB1 hypermethylated in CpG island region 
      and hypomethylated in CpG shelf region in RA patients. Outside the MHC region, 
      HDAC4, NXN, TBCD and TMEM61 were the most hypermethylated genes, while ITIH3, 
      TCN2, PRDM16, SLC1A5 and GALNT9 are the most hypomethylated genes. CONCLUSION: 
      Genome-wide DNA methylation profile revealed significant DNA methylation change 
      in CD4 + T cells from patients with RA.
FAU - Guo, Shicheng
AU  - Guo S
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
FAU - Zhu, Qi
AU  - Zhu Q
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
FAU - Jiang, Ting
AU  - Jiang T
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
AD  - b Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai 
      Chinese Medicine Research Institute , Shanghai , China.
FAU - Wang, Rongsheng
AU  - Wang R
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
AD  - b Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai 
      Chinese Medicine Research Institute , Shanghai , China.
FAU - Shen, Yi
AU  - Shen Y
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
AD  - b Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai 
      Chinese Medicine Research Institute , Shanghai , China.
FAU - Zhu, Xiao
AU  - Zhu X
AD  - c Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics , Dongguan 
      Scientific Research Center, Guangdong Medical University , Dongguan , China.
FAU - Wang, Yan
AU  - Wang Y
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
FAU - Bai, Fengmin
AU  - Bai F
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
AD  - b Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai 
      Chinese Medicine Research Institute , Shanghai , China.
FAU - Ding, Qin
AU  - Ding Q
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
AD  - b Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai 
      Chinese Medicine Research Institute , Shanghai , China.
FAU - Zhou, Xiaodong
AU  - Zhou X
AD  - d University of Texas Medical School at Houston , Houston , TX , USA , and.
FAU - Chen, Guangjie
AU  - Chen G
AD  - e Department of Immunology and Microbiology , Shanghai JiaoTong University School 
      of Medicine , Shanghai , China.
FAU - He, Dong Yi
AU  - He DY
AD  - a Department of Rheumatology , Shanghai Guanghua Hospital of Integrated 
      Traditional and Western Medicine , Shanghai , China.
AD  - b Arthritis Institute of Integrated Traditional and Western Medicine, Shanghai 
      Chinese Medicine Research Institute , Shanghai , China.
LA  - eng
PT  - Journal Article
DEP - 20160901
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/*genetics
MH  - CD4-Positive T-Lymphocytes/*metabolism
MH  - Case-Control Studies
MH  - CpG Islands
MH  - *DNA Methylation
MH  - Female
MH  - *Genome, Human
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - CD4 + T cells
OT  - DNA Methylation
OT  - Genome-wide
OT  - Illumina methylation 450k microarray
OT  - Rheumatoid arthritis
EDAT- 2016/09/03 06:00
MHDA- 2017/12/23 06:00
CRDT- 2016/09/03 06:00
PHST- 2016/09/03 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
PHST- 2016/09/03 06:00 [entrez]
AID - 10.1080/14397595.2016.1218595 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2017 May;27(3):441-447. doi: 10.1080/14397595.2016.1218595. Epub 
      2016 Sep 1.