PMID- 27586785
OWN - NLM
STAT- MEDLINE
DCOM- 20171108
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 18
IP  - 1
DP  - 2016 Sep 1
TI  - Prevalence of peripheral and extra-articular disease in ankylosing spondylitis 
      versus non-radiographic axial spondyloarthritis: a meta-analysis.
PG  - 196
LID - 10.1186/s13075-016-1093-z [doi]
LID - 196
AB  - BACKGROUND: Peripheral disease (arthritis, enthesitis and dactylitis) and 
      extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is 
      common in ankylosing spondylitis (AS) and non-radiographic axial 
      spondyloarthritis (nr-axSpA). So far, however, summary data on the prevalence are 
      lacking. The objective of this meta-analysis was to assess the prevalence of 
      peripheral and extra-articular manifestations in ankylosing spondylitis (AS) and 
      nr-axSpA. METHODS: We performed a systematic literature search to identify 
      publications describing the prevalence of peripheral and extra-articular disease 
      manifestations in patients with AS and nr-axSpA. We assessed the risk of bias and 
      between-study heterogeneity, and extracted data. Pooled prevalence and prevalence 
      differences were calculated. RESULTS: Eight studies comprising 2236 patients with 
      AS and 1242 with nr-axSpA were included: 7 of the studies were longitudinal 
      cohort studies. There was male predominance in AS (70.4 %, 95 % CI 64.4, 76.0 %) 
      but not in nr-axSpA (46.8 %, 95 % CI 41.7, 51.9), which was independent of the 
      prevalence of human leukocyte antigen (HLA)-B27. The prevalence of HLA-B27 was 
      similar in AS (78.0 % (95 % CI 73.9, 81.9 %) and nr-axSpA (77.4 %, 95 % CI 68.9, 
      84.9 %)). The pooled prevalence of arthritis (29.7 % (95 % CI 22.4, 37.4 %) 
      versus 27.9 % (95 % CI 16.0, 41.6 %)), enthesitis (28.8 % (95 % CI 2.6, 64.8) 
      versus 35.4 % (95 % CI 6.1, 71.2)). dactylitis (6.0 % (95 % CI 4.7, 7.5 %) versus 
      6.0 % (95 % CI 1.9, 12.0 %)), psoriasis (10.2 % (95 % CI 7.5, 13.2 %) versus 
      10.9 % (95 % CI 9.1, 13.0 %)) and inflammatory bowel disease (4.1 % (95 % CI 2.3, 
      6.5 %) versus 6.4 % (95 % CI 3.6, 9.7 %)) were similar in AS and nr-axSpA. The 
      pooled prevalence of uveitis was higher in AS (23.0 % (95 % CI 19.2, 27.1 %)) 
      than in nr-axSpA (15.9 % (95 % CI 11.8, 20.4 %)). CONCLUSION: Peripheral and 
      extra-articular manifestations are equally prevalent in AS and nr-axSpA, except 
      for uveitis, which is slightly more prevalent in AS. These data provide evidence 
      for the largely equal nature of disease manifestations in nr-axSpA and AS.
FAU - de Winter, Janneke J
AU  - de Winter JJ
AD  - Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and 
      immunology Center, Academic Medical Center/University of Amsterdam, Meibergdreef 
      9, 1105, AZ, Amsterdam, The Netherlands.
FAU - van Mens, Leonieke J
AU  - van Mens LJ
AD  - Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and 
      immunology Center, Academic Medical Center/University of Amsterdam, Meibergdreef 
      9, 1105, AZ, Amsterdam, The Netherlands.
FAU - van der Heijde, Desiree
AU  - van der Heijde D
AD  - Department of Rheumatology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Landewe, Robert
AU  - Landewe R
AD  - Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and 
      immunology Center, Academic Medical Center/University of Amsterdam, Meibergdreef 
      9, 1105, AZ, Amsterdam, The Netherlands.
FAU - Baeten, Dominique L
AU  - Baeten DL
AD  - Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and 
      immunology Center, Academic Medical Center/University of Amsterdam, Meibergdreef 
      9, 1105, AZ, Amsterdam, The Netherlands. d.l.baeten@amc.uva.nl.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, The Netherlands. d.l.baeten@amc.uva.nl.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20160901
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Spondylarthritis/*pathology
MH  - Spondylitis, Ankylosing/*pathology
PMC - PMC5009714
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - Axial spondyloarthritis
OT  - Extra-articular manifestations
OT  - Meta-analysis
OT  - Non-radiographic axial spondyloarthritis
OT  - Peripheral manifestations
OT  - Spondyloarthritis
EDAT- 2016/09/03 06:00
MHDA- 2017/11/09 06:00
PMCR- 2016/09/01
CRDT- 2016/09/03 06:00
PHST- 2016/03/23 00:00 [received]
PHST- 2016/08/10 00:00 [accepted]
PHST- 2016/09/03 06:00 [entrez]
PHST- 2016/09/03 06:00 [pubmed]
PHST- 2017/11/09 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 10.1186/s13075-016-1093-z [pii]
AID - 1093 [pii]
AID - 10.1186/s13075-016-1093-z [doi]
PST - epublish
SO  - Arthritis Res Ther. 2016 Sep 1;18(1):196. doi: 10.1186/s13075-016-1093-z.