PMID- 27588026
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160902
LR  - 20200929
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 7
DP  - 2016
TI  - Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter 
      Genome Function to Promote Increased Health and Lifespan.
PG  - 142
LID - 10.3389/fgene.2016.00142 [doi]
LID - 142
AB  - Caloric restriction (CR), defined as decreased nutrient intake without causing 
      malnutrition, has been documented to increase both health and lifespan across 
      numerous organisms, including humans. Many drugs and other compounds naturally 
      occurring in our diet (nutraceuticals) have been postulated to act as mimetics of 
      caloric restriction, leading to a wave of research investigating the efficacy of 
      these compounds in preventing age-related diseases and promoting healthier, 
      longer lifespans. Although well studied at the biochemical level, there are still 
      many unanswered questions about how CR and CR mimetics impact genome function and 
      structure. Here we discuss how genome function and structure are influenced by CR 
      and potential CR mimetics, including changes in gene expression profiles and 
      epigenetic modifications and their potential to identify the genetic fountain of 
      youth.
FAU - Gillespie, Zoe E
AU  - Gillespie ZE
AD  - Department of Food and Bioproduct Sciences, University of Saskatchewan Saskatoon, 
      SK, Canada.
FAU - Pickering, Joshua
AU  - Pickering J
AD  - Department of Biochemistry, University of Saskatchewan Saskatoon, SK, Canada.
FAU - Eskiw, Christopher H
AU  - Eskiw CH
AD  - Department of Food and Bioproduct Sciences, University of SaskatchewanSaskatoon, 
      SK, Canada; Department of Biochemistry, University of SaskatchewanSaskatoon, SK, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160818
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC4988992
OTO - NOTNLM
OT  - aging
OT  - caloric restriction
OT  - caloric restriction mimetics
OT  - cancer
OT  - epigenetics/genetics
OT  - gene expression
EDAT- 2016/09/03 06:00
MHDA- 2016/09/03 06:01
PMCR- 2016/08/18
CRDT- 2016/09/03 06:00
PHST- 2016/03/10 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2016/09/03 06:00 [entrez]
PHST- 2016/09/03 06:00 [pubmed]
PHST- 2016/09/03 06:01 [medline]
PHST- 2016/08/18 00:00 [pmc-release]
AID - 10.3389/fgene.2016.00142 [doi]
PST - epublish
SO  - Front Genet. 2016 Aug 18;7:142. doi: 10.3389/fgene.2016.00142. eCollection 2016.