PMID- 2758841
OWN - NLM
STAT- MEDLINE
DCOM- 19890919
LR  - 20190824
IS  - 0010-7824 (Print)
IS  - 0010-7824 (Linking)
VI  - 40
IP  - 2
DP  - 1989 Aug
TI  - The effect of the anti-progestin RU 486 on early pregnancy in the long-tailed 
      macaque (Macaca fascicularis).
PG  - 201-11
AB  - The efficacy of various doses of RU 486 in terminating pregnancy before and after 
      the luteal-placental shift (LPS) in the long-tailed macaque (Macaca fascicularis) 
      was assessed through sonographic examination and measurements of steroid hormones 
      and their metabolites. Intramuscular injection of 1.0, 2.5, 12.5, or 25.0 mg/kg 
      was administered either from gestational day (GD) 15-18 (Group 1; N = 11) or GD 
      23-26 (Group 2; N = 9). The timing of treatment was determined by the detection 
      of the preovulatory estrogen peak via daily urinary estrone conjugate (E1C) 
      measurements. In Group 1, a 90.9% pregnancy loss was observed (10/11); seven 
      animals aborted during GD 15-20, two animals indicated early embryonic death with 
      retained gestational sacs, one animal aborted on GD 56, and one pregnancy was 
      maintained. In Group 2, an 88.9% pregnancy loss was observed (8/9); eight animals 
      aborted between GD 26-29, and one pregnancy was unaffected. Hormone profiles 
      appeared to fall secondarily to the loss of trophoblast function. These results 
      indicate: (a) RU 486 was more effective after the LPS; and (b) the primary effect 
      of RU 486 appeared to be at the level of the products of conception.
FAU - Owiti, G E
AU  - Owiti GE
AD  - Department of Veterinary Anatomy, University of Nairobi.
FAU - Tarantal, A F
AU  - Tarantal AF
FAU - Lasley, B L
AU  - Lasley BL
FAU - Hendrickx, A G
AU  - Hendrickx AG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Contraception
JT  - Contraception
JID - 0234361
RN  - 0 (Abortifacient Agents)
RN  - 0 (Abortifacient Agents, Steroidal)
RN  - 0 (Contraceptives, Postcoital)
RN  - 0 (Contraceptives, Postcoital, Synthetic)
RN  - 0 (Estrenes)
RN  - 2DI9HA706A (Estrone)
RN  - 320T6RNW1F (Mifepristone)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Abortifacient Agents/*pharmacology
MH  - Abortifacient Agents, Steroidal/*pharmacology
MH  - Animals
MH  - Contraceptives, Postcoital/*pharmacology
MH  - Contraceptives, Postcoital, Synthetic/*pharmacology
MH  - Corpus Luteum/physiology
MH  - Estrenes/administration & dosage/*pharmacology
MH  - Estrone/urine
MH  - Female
MH  - Macaca fascicularis
MH  - Mifepristone
MH  - Placenta/physiology
MH  - Pregnancy
MH  - Progesterone/blood
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 0010-7824(89)90007-3 [pii]
AID - 10.1016/0010-7824(89)90007-3 [doi]
PST - ppublish
SO  - Contraception. 1989 Aug;40(2):201-11. doi: 10.1016/0010-7824(89)90007-3.