PMID- 27588422
OWN - NLM
STAT- MEDLINE
DCOM- 20170803
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 9
DP  - 2016
TI  - Epidermal Fatty Acid Binding Protein (E-FABP) Is Not Required for the Generation 
      or Maintenance of Effector and Memory T Cells following Infection with Listeria 
      monocytogenes.
PG  - e0162427
LID - 10.1371/journal.pone.0162427 [doi]
LID - e0162427
AB  - Following activation of naive T cells there are dynamic changes in the metabolic 
      pathways used by T cells to support both the energetic needs of the cell and the 
      macromolecules required for growth and proliferation. Among other changes, lipid 
      metabolism undergoes dynamic transitions between fatty acid oxidation and fatty 
      acid synthesis as cells progress from naive to effector and effector to memory T 
      cells. The hydrophobic nature of lipids requires that they be bound to protein 
      chaperones within a cell. Fatty acid binding proteins (FABPs) represent a large 
      class of lipid chaperones, with epidermal FABP (E-FABP) expressed in T cells. The 
      objective of this study was to determine the contribution of E-FABP in 
      antigen-specific T cell responses. Following infection with Listeria 
      monocytogenes, we observed similar clonal expansion, contraction and formation of 
      memory CD8 T cells in WT and E-FABP-/- mice, which also exhibited similar 
      phenotypic and functional characteristics. Analysis of Listeria-specific CD4 T 
      cells also revealed no defect in the expansion, contraction, and formation of 
      memory CD4 T cells in E-FABP-/- mice. These data demonstrate that E-FABP is 
      dispensable for antigen-specific T cell responses following a bacterial 
      infection.
FAU - Li, Bing
AU  - Li B
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, 40202, United States of America.
FAU - Schmidt, Nathan W
AU  - Schmidt NW
AD  - Department of Microbiology and Immunology, University of Louisville, Louisville, 
      KY, 40202, United States of America.
LA  - eng
GR  - R01 CA180986/CA/NCI NIH HHS/United States
GR  - R21 AI113386/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20160902
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Fabp5 protein, mouse)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Animals
MH  - Fatty Acid-Binding Proteins/genetics/*metabolism
MH  - *Immunologic Memory
MH  - Listeria monocytogenes
MH  - Listeriosis/*metabolism/microbiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - T-Lymphocytes/*metabolism/microbiology
PMC - PMC5010256
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/09/03 06:00
MHDA- 2017/08/05 06:00
PMCR- 2016/09/02
CRDT- 2016/09/03 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2016/08/22 00:00 [accepted]
PHST- 2016/09/03 06:00 [entrez]
PHST- 2016/09/03 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2016/09/02 00:00 [pmc-release]
AID - PONE-D-16-28023 [pii]
AID - 10.1371/journal.pone.0162427 [doi]
PST - epublish
SO  - PLoS One. 2016 Sep 2;11(9):e0162427. doi: 10.1371/journal.pone.0162427. 
      eCollection 2016.