PMID- 27590181
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20181113
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Print)
IS  - 1744-666X (Linking)
VI  - 13
IP  - 3
DP  - 2017 Mar
TI  - Kawasaki disease: etiopathogenesis and novel treatment strategies.
PG  - 247-258
LID - 10.1080/1744666X.2017.1232165 [doi]
AB  - Kawasaki disease is an acute febrile systemic vasculitis that predominantly 
      occurs in children below five years of age. Its etiopathogenesis is still not 
      clear, but it is thought to be a complex interplay of genetic factors, infections 
      and immunity. Areas covered: This review article discusses in detail Kawasaki 
      disease, with particular emphasis on the recent updates on its pathogenesis and 
      upcoming alternate treatment options. Though self-limiting in many cases, it can 
      lead to severe complications like coronary artery aneurysms and thrombo-embolic 
      occlusions, and hence requires early diagnosis and urgent attention to avoid 
      them. Intravenous immunoglobulin (IVIG) with or without aspirin has remained the 
      sole treatment option for these cases, but 10-15% cases develop resistance to 
      this treatment. Expert commentary: There is a need to develop additional 
      treatment strategies for children with Kawasaki disease. Targeting different 
      steps of pathogenesis could provide us with alternate therapeutic options.
FAU - Agarwal, Shreya
AU  - Agarwal S
AD  - a Department of Clinical & Translational Science , Creighton University School of 
      Medicine , Omaha , NE , USA.
FAU - Agrawal, Devendra K
AU  - Agrawal DK
AD  - a Department of Clinical & Translational Science , Creighton University School of 
      Medicine , Omaha , NE , USA.
LA  - eng
GR  - R01 HL112597/HL/NHLBI NIH HHS/United States
GR  - R01 HL116042/HL/NHLBI NIH HHS/United States
GR  - R01 HL120659/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20160913
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
RN  - 0 (Immunoglobulins, Intravenous)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Animals
MH  - Aspirin/*therapeutic use
MH  - Child, Preschool
MH  - Drug Resistance
MH  - Early Diagnosis
MH  - Gene-Environment Interaction
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Mucocutaneous Lymph Node Syndrome/diagnosis/etiology/*therapy
MH  - Remission, Spontaneous
PMC - PMC5542821
MID - NIHMS885597
OTO - NOTNLM
OT  - Coronary artery aneurysm
OT  - Kawasaki disease
OT  - intravenous immunoglobulin
OT  - refractory Kawasaki disease
OT  - thrombo-embolic occlusion
EDAT- 2016/09/04 06:00
MHDA- 2017/06/01 06:00
PMCR- 2018/03/01
CRDT- 2016/09/04 06:00
PHST- 2016/09/04 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/09/04 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1080/1744666X.2017.1232165 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2017 Mar;13(3):247-258. doi: 
      10.1080/1744666X.2017.1232165. Epub 2016 Sep 13.