PMID- 27590558
OWN - NLM
STAT- MEDLINE
DCOM- 20180208
LR  - 20180208
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 937
DP  - 2016 Sep 21
TI  - Simultaneous analysis of polychlorinated biphenyls and polychlorinated 
      naphthalenes by isotope dilution comprehensive two-dimensional gas chromatography 
      high-resolution time-of-flight mass spectrometry.
PG  - 160-7
LID - S0003-2670(16)30839-X [pii]
LID - 10.1016/j.aca.2016.07.018 [doi]
AB  - Polychlorinated biphenyls (PCBs) and polychlorinated naphthalenes (PCNs) are 
      listed as persistent organic pollutants (POPs) under the Stockholm Convention. 
      Because they have similar physical and chemical properties, they are coeluted and 
      are usually analyzed separately by different gas chromatography high-resolution 
      mass spectrometry (GC-HRMS) methods. In this study, a novel method was developed 
      for simultaneous analysis of six indicator PCBs, 12 dioxin-like PCBs, and 16 PCNs 
      using isotope dilution comprehensive two-dimensional gas chromatography with 
      high-resolution time-of-flight mass spectrometry (GC x GC-HRTOF-MS). The method 
      parameters, including the type of GC column, oven temperature program, and 
      modulation period, were systematically optimized. Complete separation of all 
      target analytes and the matrix was achieved with a DB-XLB column in the first 
      dimension and a BPX-70 column in the second dimension. The isotope dilution 
      method was used for quantification of the PCBs and PCNs by GC x GC-HRTOF-MS. The 
      method showed good linearity from 5 to 500 pg muL(-1) for all the target 
      compounds. The instrumental limit of detection ranged from 0.03 to 0.3 pg muL(-1) 
      for the 18 PCB congeners and from 0.09 to 0.6 pg muL(-1) for the 16 PCN congeners. 
      Repeatability for triplicate injections was always lower than 20%. The method was 
      successfully applied to the determination of 18 PCBs present at 0.9-2054 pg g(-1) 
      and 16 PCNs present at 0.2-15.7 pg g(-1) in three species of fish. The 
      GC x GC-HRTOF-MS results agreed with those obtained by GC-HRMS. The 
      GC x GC-HRTOF-MS method proved to be a sensitive and accurate technique for 
      simultaneous analysis of the selected PCBs and PCNs. With the excellent 
      chromatographic separation offered by GC x GC and accurate mass measurements 
      offered by HRTOF-MS, this method allowed identification of non-target 
      contaminants in the fish samples, including organochlorine pesticides and 
      polycyclic aromatic hydrocarbons.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Xia, Dan
AU  - Xia D
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China; University of Chinese Academy of Sciences, Beijing 100085, China.
FAU - Gao, Lirong
AU  - Gao L
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China. Electronic address: gaolr@rcees.ac.cn.
FAU - Zheng, Minghui
AU  - Zheng M
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
FAU - Wang, Shasha
AU  - Wang S
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
FAU - Liu, Guorui
AU  - Liu G
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 
      100085, China.
LA  - eng
PT  - Journal Article
DEP - 20160725
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Naphthalenes)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hydrocarbons, Chlorinated/*analysis
MH  - *Indicator Dilution Techniques
MH  - Naphthalenes/*analysis
MH  - Polychlorinated Biphenyls/*analysis
MH  - Time Factors
OTO - NOTNLM
OT  - Comprehensive two-dimensional gas chromatography
OT  - High-resolution time-of-flight mass spectrometry
OT  - Polychlorinated biphenyls
OT  - Polychlorinated naphthalenes
EDAT- 2016/09/04 06:00
MHDA- 2018/02/09 06:00
CRDT- 2016/09/04 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2016/07/12 00:00 [revised]
PHST- 2016/07/15 00:00 [accepted]
PHST- 2016/09/04 06:00 [entrez]
PHST- 2016/09/04 06:00 [pubmed]
PHST- 2018/02/09 06:00 [medline]
AID - S0003-2670(16)30839-X [pii]
AID - 10.1016/j.aca.2016.07.018 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2016 Sep 21;937:160-7. doi: 10.1016/j.aca.2016.07.018. Epub 2016 
      Jul 25.