PMID- 27593396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Jan
TI  - Dyslipidaemia and its treatment in patients with type 2 diabetes: A joint 
      analysis of the German DIVE and DPV registries.
PG  - 61-69
LID - 10.1111/dom.12783 [doi]
AB  - AIMS: To compare lipid abnormalities in people with and without type 2 diabetes 
      mellitus (T2DM) and to assess the effect of treatment. MATERIALS AND METHODS: We 
      combined data from the German DIVE (DIabetes Versorgungs-Evaluation) and DPV 
      (Diabetes-Patienten-Verlaufsdokumentation) databases to produce a large cohort of 
      people with T2DM. The characteristics of people receiving and not receiving 
      lipid-modifying therapy (LMT) were compared, including demographics, 
      cardiovascular (CV) risk factors and comorbidities. Lipid profiles were 
      evaluated, and the achievement of recommended LDL cholesterol and non-HDL 
      cholesterol targets was assessed. The effect on lipid levels in subgroups of 
      patients aged >/=60 years, being obese or with CV disease was also investigated. 
      RESULTS: A total of 363 949 people were included in the analysis. Of these, only 
      97 160 (26.7%) were receiving LMT. These individuals were older than those not 
      receiving LMT, and comorbidities were more prevalent. Statins were the most 
      commonly used agents (84.2%), with ezetimibe, fibrates and nicotinic acid taken 
      by a small proportion of people. The median LDL cholesterol level was lower for 
      the LMT group (100.5 vs 114.0 mg/dL; P < .001), as was the non-HDL cholesterol 
      level (131.0 vs 143.1 mg/dL; P < .001), while the triglyceride level was higher 
      (160.3 vs 152.0 mg/dL; P < .001). HDL cholesterol was lower in the LMT group for 
      both men (41.0 vs 42.0 mg/dL; P < .001) and women (47.5 vs 48.0 mg/dL; P < .001). 
      Elderly people were more likely to have achieved the target lipid levels, while 
      obese people were less likely. For people with CV disease, there was a greater 
      likelihood of achieving LDL, total and non-HDL cholesterol targets, but less 
      chance of attaining a desired HDL cholesterol level. CONCLUSIONS: Dyslipidaemia 
      was highly prevalent in this large population and management of lipid 
      abnormalities was suboptimal. The distinct lipid profile of people with T2DM 
      warrants further investigation into the use of non-statins in addition to statin 
      LMT.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Bramlage, Peter
AU  - Bramlage P
AD  - Institute for Pharmacology and Preventative Medicine, Mahlow, Germany. 
      peter.bramlage@ippmed.de.
FAU - Lanzinger, Stefanie
AU  - Lanzinger S
AD  - ZIBMT, Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, 
      Germany.
AD  - Deutsches Diabetes Zentrum, Munchen-Neuherberg, Germany.
FAU - Rathmann, Wolfgang
AU  - Rathmann W
AD  - Institute of Biometry and Epidemiology, Deutsches Diabetes Zentrum, Dusseldorf, 
      Germany.
FAU - Gillessen, Anton
AU  - Gillessen A
AD  - Herz-Jesu-Krankenhaus Munster, Munster, Germany.
FAU - Scheper, Nikolaus
AU  - Scheper N
AD  - Diabetesschwerpunktpraxis, Marl, Germany.
FAU - Schmid, Sebastian M
AU  - Schmid SM
AD  - Medizinische Klinik 1, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany.
AD  - Deutsches Diabetes Zentrum, Lubeck, Germany.
FAU - Kaltheuner, Matthias
AU  - Kaltheuner M
AD  - Diabetesschwerpunktpraxis, Leverkusen, Germany.
FAU - Seufert, Jochen
AU  - Seufert J
AD  - Department of Internal Medicine, Universitatsklinikum Freiburg, Freiburg, 
      Germany.
FAU - Danne, Thomas
AU  - Danne T
AD  - Diabeteszentrum fur Kinder und Jugendliche, Kinderkrankenhaus auf der Bult, 
      Hannover, Germany.
FAU - Holl, Reinhard W
AU  - Holl RW
AD  - ZIBMT, Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, 
      Germany.
AD  - Deutsches Diabetes Zentrum, Munchen-Neuherberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160904
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
OTO - NOTNLM
OT  - age
OT  - cardiovascular
OT  - cholesterol
OT  - diabetes
OT  - lipids
OT  - obesity
OT  - statins
OT  - triglycerides
EDAT- 2016/09/07 06:00
MHDA- 2016/09/07 06:01
CRDT- 2016/09/06 06:00
PHST- 2016/07/11 00:00 [received]
PHST- 2016/08/20 00:00 [revised]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/09/06 06:00 [entrez]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2016/09/07 06:01 [medline]
AID - 10.1111/dom.12783 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2017 Jan;19(1):61-69. doi: 10.1111/dom.12783. Epub 2016 Sep 
      4.