PMID- 27593703
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20181113
IS  - 2049-9957 (Electronic)
IS  - 2049-9957 (Linking)
VI  - 5
IP  - 1
DP  - 2016 Sep 5
TI  - High HIV incidence epidemic among men who have sex with men in china: results 
      from a multi-site cross-sectional study.
PG  - 82
LID - 10.1186/s40249-016-0178-x [doi]
LID - 82
AB  - BACKGROUND: Recent upsurge of new HIV infections among men who have sex with men 
      (MSM) is a major concern in China. Paucity of national-level information 
      regarding the burden and predictors of this progressive epidemic of new 
      infections called for a multi-centric, timely and comprehensive investigation. 
      METHODS: Mixed methods were used to recruit MSM from seven cities in China 
      between 2012 and 2013. Recent and established HIV infections were estimated by 
      Western Blot and BED HIV-1 capture enzyme immunoassay. Syphilis and herpes 
      simplex virus-2 (HSV-2) were also tested. RESULTS: A total of 4496 eligible MSM 
      were recruited. The majority was aged </=35 years (77.5 %), migrants (60.3 %), 
      never married (69.8 %), and played receptive role in anal sex (70.5 %). The HIV 
      prevalence was 9.9 %, and 41.9 % were recently infected, with 
      sensitivity/specificity adjusted HIV incidence of 8.9 (95 % CI: 7.6-10.2)/100 
      Person-Years. The prevalence of history HSV-2 and syphilis were 12.5 % and 8.5 %, 
      respectively. Recent HIV infection was associated with having multiple male 
      partners (aOR = 1.4, 95 % CI 1.1-1.9), recreational drug use (aOR = 2.2, 95 % CI 
      1.6-3.0), anal bleeding (aOR = 2.1, 95 % CI 1.4-3.0), syphilis infection 
      (aOR = 2.8, 95 % CI 1.9-4.3) and history HSV-2 infection (aOR = 2.3, 95 % CI 
      1.5-3.3). CONCLUSION: High rate of recent HIV infection is potentially resulting 
      in progressive deterioration of the overall HIV epidemic among MSM in China. 
      Targeted interventions to address high-risk MSM including those having multiple 
      partners, history of recreational drug use and syphilis or HSV-2 infection seemed 
      to be the need of the hour.
FAU - Xu, Jun-Jie
AU  - Xu JJ
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Tang, Wei-Ming
AU  - Tang WM
AD  - University of North Carolina at Chapel Hill, Project-China, No. 2 Lujing Road, 
      Guangzhou, 510085, People's Republic of China.
AD  - Guangdong Provincial Center for Skin Diseases and STIs Control, Guangzhou, 
      510085, People's Republic of China.
FAU - Zou, Hua-Chun
AU  - Zou HC
AD  - Kirby Institute, the University of New South Wales, Sydney, NSW, 2052, Australia.
FAU - Mahapatra, Tanmay
AU  - Mahapatra T
AD  - Department of Epidemiology, Fielding School of Public Health, University of 
      California, Los Angeles, 90095, USA.
FAU - Hu, Qing-Hai
AU  - Hu QH
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Fu, Geng-Feng
AU  - Fu GF
AD  - Jiangsu Provincial Centers for Disease Control and Prevention, Nanjing, China.
FAU - Wang, Zhe
AU  - Wang Z
AD  - He'nan Provincial Centers for Disease Control and Prevention, Zhengzhou, China.
FAU - Lu, Lin
AU  - Lu L
AD  - Yunnan Provincial Centers for Disease Control and Prevention, Kunming, China.
FAU - Zhuang, Ming-Hua
AU  - Zhuang MH
AD  - Shanghai Municipal Centers for Disease Control and Prevention, Shanghai, China.
FAU - Chen, Xi
AU  - Chen X
AD  - Hu'nan Provincial Centers for Disease Control and Prevention, Changsha, China.
FAU - Fu, Ji-Hua
AU  - Fu JH
AD  - Shandong Provincial Centers for Disease Control and Prevention, Jinan, China.
FAU - Yu, Yan-Qiu
AU  - Yu YQ
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Lu, Jin-Xin
AU  - Lu JX
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Jiang, Yong-Jun
AU  - Jiang YJ
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Geng, Wen-Qing
AU  - Geng WQ
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Han, Xiao-Xu
AU  - Han XX
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China.
FAU - Shang, Hong
AU  - Shang H
AUID- ORCID: 0000-0003-4303-7295
AD  - Key Laboratory of AIDS Immunology of National Health and Family Planning 
      Commission, Department of Laboratory Medicine, The First Affiliated Hospital, 
      China Medical University, Shenyang, 110001, People's Republic of China. 
      hongshang100@hotmail.com.
AD  - Collaborative Innovation Center for Diagnosis and Treatment of Infectious 
      Diseases, Hangzhou, People's Republic of China. hongshang100@hotmail.com.
LA  - eng
GR  - D43 TW009532/TW/FIC NIH HHS/United States
GR  - R01 AI114310/AI/NIAID NIH HHS/United States
GR  - R25 TW009340/TW/FIC NIH HHS/United States
PT  - Journal Article
DEP - 20160905
PL  - England
TA  - Infect Dis Poverty
JT  - Infectious diseases of poverty
JID - 101606645
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - *Epidemics
MH  - HIV Infections/*epidemiology
MH  - *Homosexuality, Male
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
PMC - PMC5011347
OTO - NOTNLM
OT  - BED HIV-1 capture enzyme immunoassay (BED-CEIA)
OT  - HIV
OT  - Incidence
OT  - Men who have sex with men (MSM)
EDAT- 2016/09/07 06:00
MHDA- 2017/02/09 06:00
PMCR- 2016/09/05
CRDT- 2016/09/06 06:00
PHST- 2016/01/07 00:00 [received]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/09/06 06:00 [entrez]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
PHST- 2016/09/05 00:00 [pmc-release]
AID - 10.1186/s40249-016-0178-x [pii]
AID - 178 [pii]
AID - 10.1186/s40249-016-0178-x [doi]
PST - epublish
SO  - Infect Dis Poverty. 2016 Sep 5;5(1):82. doi: 10.1186/s40249-016-0178-x.