PMID- 27593929
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20200502
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 36
IP  - 12
DP  - 2017 Mar 23
TI  - Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast 
      cancer.
PG  - 1745-1752
LID - 10.1038/onc.2016.327 [doi]
AB  - Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. 
      However, the regulatory mechanisms by which MSI2 alters breast cancer 
      pathophysiology have not been clearly identified. Here we demonstrate that MSI2 
      directly regulates estrogen receptor 1 (ESR1), which is a well-known therapeutic 
      target and has been shown to reflect clinical outcomes in breast cancer. Based on 
      gene expression data analysis, we found that MSI2 expression was highly enriched 
      in estrogen receptor (ER)-positive breast cancer and that MSI2 expression was 
      significantly correlated with ESR1 expression, including expression of ESR1 
      downstream target genes. In addition, MSI2 levels were associated with clinical 
      outcomes. MSI2 influenced breast cancer cell growth by altering ESR1 function. 
      MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 
      protein stability. Taken together, our findings identified a novel regulatory 
      mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical 
      relevance of the RNA-binding protein MSI2 in breast cancer.
FAU - Kang, M-H
AU  - Kang MH
AD  - Department of Convergence Medicine, Ulsan College of Medicine, Seoul, South 
      Korea.
FAU - Jeong, K J
AU  - Jeong KJ
AD  - Department of Systems Biology, MD Anderson Cancer Center, Houston, TX, USA.
FAU - Kim, W Y
AU  - Kim WY
AD  - Department of Surgery, Korea University, Guro Hospital, Seoul, South Korea.
FAU - Lee, H J
AU  - Lee HJ
AD  - Department of Pathology, ASAN Medical Center, Seoul, South Korea.
FAU - Gong, G
AU  - Gong G
AD  - Department of Pathology, ASAN Medical Center, Seoul, South Korea.
FAU - Suh, N
AU  - Suh N
AD  - Department of Medicine Engineering, College of Medical Sciences, Soon Chun Hyang 
      University, Asan-si, South Korea.
FAU - Gyorffy, B
AU  - Gyorffy B
AD  - MTA TTK Lendulet Cancer Biomarker Research Group, Semmelweis University 2nd 
      Department of Pediatrics, Budapest, Hungary.
FAU - Kim, S
AU  - Kim S
AD  - Anging Research Institute, Korea Research Institute of Bioscience and 
      Biotechnology, Daejeon, South Korea.
FAU - Jeong, S-Y
AU  - Jeong SY
AD  - Department of Convergence Medicine, Ulsan College of Medicine, Seoul, South 
      Korea.
AD  - ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, South Korea.
FAU - Mills, G B
AU  - Mills GB
AD  - Department of Systems Biology, MD Anderson Cancer Center, Houston, TX, USA.
FAU - Park, Y-Y
AU  - Park YY
AD  - Department of Convergence Medicine, Ulsan College of Medicine, Seoul, South 
      Korea.
AD  - ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160905
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Biomarkers)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (MSI2 protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
EIN - Oncogene. 2019 May;38(22):4427-4428. PMID: 30718918
MH  - Biomarkers
MH  - Breast Neoplasms/genetics/*metabolism/mortality
MH  - Cell Line, Tumor
MH  - Cluster Analysis
MH  - Estrogen Receptor alpha/genetics/*metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Prognosis
MH  - Protein Binding
MH  - Protein Stability
MH  - RNA-Binding Proteins/genetics/*metabolism
EDAT- 2016/09/07 06:00
MHDA- 2017/09/02 06:00
CRDT- 2016/09/06 06:00
PHST- 2016/03/01 00:00 [received]
PHST- 2016/07/03 00:00 [revised]
PHST- 2016/07/28 00:00 [accepted]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
PHST- 2016/09/06 06:00 [entrez]
AID - onc2016327 [pii]
AID - 10.1038/onc.2016.327 [doi]
PST - ppublish
SO  - Oncogene. 2017 Mar 23;36(12):1745-1752. doi: 10.1038/onc.2016.327. Epub 2016 Sep 
      5.