PMID- 27596021
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20231213
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 88
IP  - 4
DP  - 2016 Oct
TI  - Distribution of HLA-G extended haplotypes and one HLA-E polymorphism in a 
      large-scale study of mother-child dyads with and without severe preeclampsia and 
      eclampsia.
PG  - 172-86
LID - 10.1111/tan.12871 [doi]
AB  - The etiological pathways and pathogenesis of preeclampsia have rendered difficult 
      to disentangle. Accumulating evidence points toward a maladapted maternal immune 
      system, which may involve aberrant placental expression of immunomodulatory human 
      leukocyte antigen (HLA) class Ib molecules during pregnancy. Several studies have 
      shown aberrant or reduced expression of HLA-G in the placenta and in maternal 
      blood in cases of preeclampsia compared with controls. Unlike classical HLA class 
      Ia loci, the nonclassical HLA-G has limited polymorphic variants. Most nucleotide 
      variations are clustered in the 5'-upstream regulatory region (5'URR) and 
      3'-untranslated regulatory region (3'UTR) of HLA-G and reflect a stringent 
      expressional control. Based on genotyping and full gene sequencing of HLA-G in a 
      large number of cases and controls (n > 900), the present study, which to our 
      knowledge is the largest and most comprehensive performed, investigated the 
      association between the HLA-G 14-bp ins/del (rs66554220) and HLA-E polymorphisms 
      in mother and newborn dyads from pregnancies complicated by severe 
      preeclampsia/eclampsia and from uncomplicated pregnancies. Furthermore, results 
      from extended HLA-G haplotyping in the newborns are presented in order to assess 
      whether a combined contribution of nucleotide variations spanning the 5'URR, 
      coding region, and 3'UTR of HLA-G describes the genetic association with severe 
      preeclampsia more closely. In contrast to earlier findings, the HLA-G 14-bp 
      ins/del polymorphism was not associated with severe preeclampsia. Furthermore, 
      the polymorphism (rs1264457) defining the two nonsynonymous HLA-E alleles, 
      HLA-E*01:01:xx:xx and HLA-E*01:03:xx:xx, were not associated with severe 
      preeclampsia. Finally, no specific HLA-G haplotypes were significantly associated 
      with increased risk of developing severe preeclampsia/eclampsia.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Nilsson, L L
AU  - Nilsson LL
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital (Roskilde), 
      Roskilde, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Djurisic, S
AU  - Djurisic S
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital (Roskilde), 
      Roskilde, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Andersen, A-M N
AU  - Andersen AM
AD  - Department of Public Health, Section of Social Medicine, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Melbye, M
AU  - Melbye M
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
AD  - Department of Medicine, Stanford University School of Medicine, Stanford, CA, 
      USA.
FAU - Bjerre, D
AU  - Bjerre D
AD  - Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, 
      Copenhagen University Hospital, Roskilde, Denmark.
FAU - Ferrero-Miliani, L
AU  - Ferrero-Miliani L
AD  - Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, 
      Copenhagen University Hospital, Roskilde, Denmark.
FAU - Hackmon, R
AU  - Hackmon R
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 
      USA.
FAU - Geraghty, D E
AU  - Geraghty DE
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 
      USA.
FAU - Hviid, T V F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital (Roskilde), 
      Roskilde, Denmark. tvh@regionsjaelland.dk.
AD  - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 
      tvh@regionsjaelland.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160906
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Case-Control Studies
MH  - Child
MH  - Eclampsia/diagnosis/*genetics/immunology/pathology
MH  - Female
MH  - Gene Expression
MH  - HLA-G Antigens/*genetics/immunology
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - *INDEL Mutation
MH  - Infant, Newborn
MH  - Male
MH  - Placenta/immunology/pathology
MH  - *Polymorphism, Single Nucleotide
MH  - Pre-Eclampsia/diagnosis/*genetics/immunology/pathology
MH  - Pregnancy
MH  - Sequence Analysis, DNA
MH  - Severity of Illness Index
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - HLA-E
OT  - HLA-G
OT  - haplotypes
OT  - preeclampsia
OT  - pregnancy
EDAT- 2016/09/07 06:00
MHDA- 2018/01/18 06:00
CRDT- 2016/09/07 06:00
PHST- 2016/06/03 00:00 [received]
PHST- 2016/07/29 00:00 [revised]
PHST- 2016/08/10 00:00 [accepted]
PHST- 2016/09/07 06:00 [entrez]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
AID - 10.1111/tan.12871 [doi]
PST - ppublish
SO  - HLA. 2016 Oct;88(4):172-86. doi: 10.1111/tan.12871. Epub 2016 Sep 6.