PMID- 27596058
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 120
DP  - 2016 Oct
TI  - Do worms protect against the metabolic syndrome? A systematic review and 
      meta-analysis.
PG  - 209-20
LID - S0168-8227(16)30437-5 [pii]
LID - 10.1016/j.diabres.2016.08.014 [doi]
AB  - AIMS: There is increasing evidence on the role of helminth infections in 
      modifying autoimmune and allergic diseases. These infections may have similar 
      effect in other inflammatory processes, such as insulin resistance. This review 
      aims to examine the literature on the effect of helminthic infections on 
      metabolic outcomes in humans. METHODS: Using the PRISMA protocol, we searched the 
      literature using PubMed, MEDLINE, and a manual review of reference lists. Human 
      studies published in English after 1995 were included. Four papers were included 
      in this review. Data was extracted and a meta-analysis was conducted using a 
      random-effects model. Heterogeneity was assessed using Tau(2) and I(2) tests. 
      RESULTS: The included studies found that infection was associated with lower 
      glucose levels, less insulin resistance, and/or a lower prevalence of metabolic 
      syndrome (MetS) or type 2 diabetes mellitus (T2DM). Meta-analysis showed that 
      participants with a previous or current helminth infection were 50% less likely 
      to have an endpoint of metabolic dysfunction in comparison to uninfected 
      participants (OR 0.50; 95% CI 0.38-0.66). CONCLUSION: This review has shown that 
      helminth infections can be associated with improved metabolic outcomes. 
      Understanding of the mechanisms underlying this relationship could facilitate the 
      development of novel strategies to prevent or delay T2DM.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Tracey, Ella F
AU  - Tracey EF
AD  - College of Medicine & Dentistry, Division of Tropical Health and Medicine, James 
      Cook University, Cairns, QLD, Australia. Electronic address: 
      ella.tracey@my.jcu.edu.au.
FAU - McDermott, Robyn A
AU  - McDermott RA
AD  - Centre for Chronic Disease Prevention, Australian Institute of Tropical Health 
      and Medicine, James Cook University, Cairns, QLD, Australia.
FAU - McDonald, Malcolm I
AU  - McDonald MI
AD  - College of Medicine & Dentistry, Division of Tropical Health and Medicine, James 
      Cook University, Cairns, QLD, Australia; Centre for Chronic Disease Prevention, 
      Australian Institute of Tropical Health and Medicine, James Cook University, 
      Cairns, QLD, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20160825
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*immunology/parasitology
MH  - Helminthiasis/*immunology
MH  - Humans
MH  - Insulin Resistance/immunology
MH  - Metabolic Syndrome/*immunology/parasitology
MH  - Protective Factors
MH  - Schistosoma/immunology
MH  - Trichuris/immunology
OTO - NOTNLM
OT  - Helminths
OT  - Immunology
OT  - Metabolic syndrome
OT  - Type 2 diabetes mellitus
EDAT- 2016/09/07 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/09/07 06:00
PHST- 2016/05/20 00:00 [received]
PHST- 2016/06/29 00:00 [revised]
PHST- 2016/08/19 00:00 [accepted]
PHST- 2016/09/07 06:00 [entrez]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0168-8227(16)30437-5 [pii]
AID - 10.1016/j.diabres.2016.08.014 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2016 Oct;120:209-20. doi: 10.1016/j.diabres.2016.08.014. 
      Epub 2016 Aug 25.