PMID- 27596383
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20181202
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Sep 6
TI  - Alpha-glucosidase inhibitors and hepatotoxicity in type 2 diabetes: a systematic 
      review and meta-analysis.
PG  - 32649
LID - 10.1038/srep32649 [doi]
LID - 32649
AB  - Alpha-glucosidase inhibitors (AGIs) was reported to be associated with several 
      rare adverse hepatic events, but with inconsistent results. We aimed to 
      investigate the risk of hepatotoxicity associated with the use of AGIs in 
      patients with type 2 diabetes mellitus (T2DM), and performed a systematic review 
      and meta-analysis. Fourteen studies (n = 2881) were eligible, all of which were 
      RCTs. Meta-analysis of data regarding elevation of more than 3-fold the upper 
      limit of normal (ULN) of AST and ALT showed statistically significant differences 
      between AGIs treatment versus control (OR 6.86, 95% CI 2.50 to 18.80; OR 6.48, 
      95% CI 2.40 to 17.49). Subgroup analyses of elevation of more than 1.8-fold ULN 
      of AST and ALT by dose of AGIs showed differential effects on AST and ALT (AST: 
      OR 0.38 vs 7.31, interaction P = 0.003; ALT: OR 0.32 vs 4.55, interaction 
      p = 0.02). Meta-analysis showed that AGIs might increase the risk of 
      hepatotoxicity, and higher dose appeared to be associated with higher risk of 
      hepatotoxicity. However, the evidence is limited with surrogate measures (i.e. 
      ALT and AST), and no clinically important adverse events were observed.
FAU - Zhang, Longhao
AU  - Zhang L
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Chen, Qiyan
AU  - Chen Q
AD  - West China School of Public Health; Sichuan University, Chengdu 610041, China.
FAU - Li, Ling
AU  - Li L
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Kwong, Joey S W
AU  - Kwong JS
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Jia, Pengli
AU  - Jia P
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Zhao, Pujing
AU  - Zhao P
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Wang, Wen
AU  - Wang W
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Zhou, Xu
AU  - Zhou X
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Zhang, Mingming
AU  - Zhang M
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Sun, Xin
AU  - Sun X
AD  - Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20160906
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/metabolism
MH  - Aspartate Aminotransferases/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/enzymology
MH  - Glycoside Hydrolase Inhibitors/*adverse effects/*therapeutic use
MH  - Humans
MH  - Liver/drug effects/*pathology
MH  - Middle Aged
MH  - Publication Bias
PMC - PMC5011653
EDAT- 2016/09/07 06:00
MHDA- 2018/05/22 06:00
PMCR- 2016/09/06
CRDT- 2016/09/07 06:00
PHST- 2016/03/01 00:00 [received]
PHST- 2016/08/11 00:00 [accepted]
PHST- 2016/09/07 06:00 [entrez]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2016/09/06 00:00 [pmc-release]
AID - srep32649 [pii]
AID - 10.1038/srep32649 [doi]
PST - epublish
SO  - Sci Rep. 2016 Sep 6;6:32649. doi: 10.1038/srep32649.