PMID- 2759715
OWN - NLM
STAT- MEDLINE
DCOM- 19890920
LR  - 20190816
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 89
IP  - 2-3
DP  - 1989
TI  - Natural killer susceptibility of brain tumor cell lines inversely correlates with 
      the degree of cell differentiation and not with the level of human 
      histocompatibility antigen expression.
PG  - 169-72
AB  - The purpose of this paper is to investigate the natural killer (NK) sensitivity 
      of 15 cell lines derived from human brain tumors expressing different levels of 
      major histocompatibility complex (MHC) antigens. Although it has recently been 
      reported that NK susceptibility varies inversely with target cell class-I human 
      leukocyte antigen (HLA) expression, our results show no correlation between 
      class-I HLA, class-II HLA or beta 2-microglobulin expression on target cells and 
      NK sensitivity, whereas a significant inverse correlation between NK 
      susceptibility and the degree of tumor cell differentiation has been found. Thus, 
      poorly differentiated tumor cells are highly susceptible to NK lysis, whereas 
      well-differentiated ones are NK resistant. These results suggest that sensitivity 
      to lysis by NK cells of cell lines derived from human brain tumors is primarily 
      determined by the stage of differentiation and not by the level of MHC antigen 
      expression on target cell.
FAU - Alonso, C
AU  - Alonso C
AD  - Department of Biochemistry, Faculty of Medicine, Reina Sofia Hospital, University 
      of Cordoba, Spain.
FAU - Serrano, R
AU  - Serrano R
FAU - Solana, R
AU  - Solana R
FAU - Pena, J
AU  - Pena J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Brain Neoplasms/*immunology/pathology
MH  - Cell Differentiation
MH  - Cytotoxicity, Immunologic
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - In Vitro Techniques
MH  - Killer Cells, Natural/*immunology
MH  - Tumor Cells, Cultured
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1159/000234941 [doi]
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1989;89(2-3):169-72. doi: 10.1159/000234941.