PMID- 27597545
OWN - NLM
STAT- MEDLINE
DCOM- 20180315
LR  - 20211204
IS  - 1932-846X (Electronic)
IS  - 1932-8451 (Print)
IS  - 1932-8451 (Linking)
VI  - 77
IP  - 6
DP  - 2017 Jun
TI  - Impact of exercise and a complex environment on hippocampal dendritic morphology, 
      Bdnf gene expression, and DNA methylation in male rat pups neonatally exposed to 
      alcohol.
PG  - 708-725
LID - 10.1002/dneu.22448 [doi]
AB  - Alcohol exposure in utero can result in Fetal Alcohol Spectrums Disorders (FASD). 
      Measures of hippocampal neuroplasticity, including long-term potentiation, 
      synaptic and dendritic organization, and adult neurogenesis, are consistently 
      disrupted in rodent models of FASD. The current study investigated whether third 
      trimester-equivalent binge-like alcohol exposure (AE) [postnatal days (PD) 4-9] 
      affects dendritic morphology of immature dentate gyrus granule cells, and 
      brain-derived neurotrophic factor (Bdnf) gene expression and DNA methylation in 
      hippocampal tissue in adult male rats. To understand immediate impact of alcohol, 
      DNA methylation was measured in the PD10 hippocampus. In addition, two behavioral 
      interventions, wheel running (WR) and environmental complexity (EC), were 
      utilized as rehabilitative therapies for alcohol-induced deficits. AE 
      significantly decreased dendritic complexity of the immature neurons, 
      demonstrating the long-lasting impact of neonatal alcohol exposure on dendritic 
      morphology of immature neurons in the hippocampus. Both housing conditions 
      robustly enhanced dendritic complexity in the AE animals. While Bdnf exon I DNA 
      methylation was lower in the AE and sham-intubated animals compared with suckle 
      controls on PD10, alterations to Bdnf DNA methylation and gene expression levels 
      were not present at PD72. In control animals, exercise, but not exercise followed 
      by housing in EC, resulted in higher levels of hippocampal Bdnf gene expression 
      and lower DNA methylation. These studies demonstrate the long-lasting negative 
      impact of developmental alcohol exposure on hippocampal dendritic morphology and 
      support the implementation of exercise and complex environments as therapeutic 
      interventions for individuals with FASD. (c) 2016 Wiley Periodicals, Inc. Develop 
      Neurobiol 77: 708-725, 2017.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Boschen, K E
AU  - Boschen KE
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      Delaware, 19716.
FAU - McKeown, S E
AU  - McKeown SE
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      Delaware, 19716.
FAU - Roth, T L
AU  - Roth TL
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      Delaware, 19716.
FAU - Klintsova, A Y
AU  - Klintsova AY
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      Delaware, 19716.
LA  - eng
GR  - P20 GM103653/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20160921
PL  - United States
TA  - Dev Neurobiol
JT  - Developmental neurobiology
JID - 101300215
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Central Nervous System Depressants/pharmacology
MH  - DNA Methylation/*drug effects
MH  - Dendrites/*drug effects
MH  - Doublecortin Domain Proteins
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - Hippocampus/cytology
MH  - Locomotion/drug effects
MH  - Male
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurons/*cytology/drug effects
MH  - Neuropeptides/metabolism
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Long-Evans
PMC - PMC5997455
MID - NIHMS971741
OTO - NOTNLM
OT  - DNA methylation
OT  - adult neurogenesis
OT  - alcohol
OT  - development
OT  - plasticity
EDAT- 2016/09/07 06:00
MHDA- 2018/03/16 06:00
PMCR- 2018/06/12
CRDT- 2016/09/07 06:00
PHST- 2016/06/01 00:00 [received]
PHST- 2016/08/23 00:00 [revised]
PHST- 2016/09/01 00:00 [accepted]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2018/03/16 06:00 [medline]
PHST- 2016/09/07 06:00 [entrez]
PHST- 2018/06/12 00:00 [pmc-release]
AID - 10.1002/dneu.22448 [doi]
PST - ppublish
SO  - Dev Neurobiol. 2017 Jun;77(6):708-725. doi: 10.1002/dneu.22448. Epub 2016 Sep 21.