PMID- 27597804
OWN - NLM
STAT- MEDLINE
DCOM- 20170605
LR  - 20181113
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2016
DP  - 2016
TI  - Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?
PG  - 3481371
LID - 10.1155/2016/3481371 [doi]
LID - 3481371
AB  - Inflammation is a protective response of the organism to tissue injury or 
      infection. It occurs when the immune system recognizes Pathogen-Associated 
      Molecular Patterns (PAMPs) or Damage-Associated Molecular Pattern (DAMPs) through 
      the activation of Pattern Recognition Receptors. This initiates a variety of 
      signalling events that conclude in the upregulation of proinflammatory molecules, 
      which initiate an appropriate immune response. This response is tightly regulated 
      since any aberrant activation of immune responses would have severe pathological 
      consequences such as sepsis or chronic inflammatory and autoimmune diseases. 
      Accumulative evidence shows that the ubiquitin system, and in particular 
      ubiquitin-specific isopeptidases also known as deubiquitinases (DUBs), plays 
      crucial roles in the control of these immune pathways. In this review we will 
      give an up-to-date overview on the role of DUBs in the NF-kappaB pathway and 
      inflammasome activation, two intrinsically related events triggered by activation 
      of the membrane TLRs as well as the cytosolic NOD and NLR receptors. Modulation 
      of DUB activity by small molecules has been proposed as a way to control 
      dysregulation or overactivation of these key players of the inflammatory 
      response. We will also discuss the advances and challenges of a potential use of 
      DUBs as therapeutic targets in inflammatory pathologies.
FAU - Lopez-Castejon, Gloria
AU  - Lopez-Castejon G
AUID- ORCID: 0000-0002-8585-3381
AD  - Manchester Collaborative Centre for Inflammation Research, University of 
      Manchester, 46 Grafton Street, Manchester M13 9NT, UK.
FAU - Edelmann, Mariola J
AU  - Edelmann MJ
AUID- ORCID: 0000-0003-0459-7716
AD  - Department of Microbiology and Cell Science, College of Agricultural and Life 
      Sciences, University of Florida, 1355 Museum Drive, Gainesville, FL 32611-0700, 
      USA.
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20160814
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Alarmins)
RN  - 0 (Pathogen-Associated Molecular Pattern Molecules)
RN  - EC 3.4.19.12 (Deubiquitinating Enzymes)
SB  - IM
MH  - Alarmins/metabolism
MH  - Animals
MH  - Deubiquitinating Enzymes/*metabolism
MH  - Humans
MH  - Inflammation/metabolism
MH  - Pathogen-Associated Molecular Pattern Molecules/metabolism
MH  - Signal Transduction/physiology
PMC - PMC5002299
EDAT- 2016/09/07 06:00
MHDA- 2017/06/06 06:00
PMCR- 2016/08/14
CRDT- 2016/09/07 06:00
PHST- 2016/03/24 00:00 [received]
PHST- 2016/06/01 00:00 [revised]
PHST- 2016/07/04 00:00 [accepted]
PHST- 2016/09/07 06:00 [entrez]
PHST- 2016/09/07 06:00 [pubmed]
PHST- 2017/06/06 06:00 [medline]
PHST- 2016/08/14 00:00 [pmc-release]
AID - 10.1155/2016/3481371 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2016;2016:3481371. doi: 10.1155/2016/3481371. Epub 2016 Aug 
      14.