PMID- 27599418
OWN - NLM
STAT- MEDLINE
DCOM- 20170210
LR  - 20171018
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 57
IP  - 8
DP  - 2016 Aug
TI  - [Mantle cell lymphoma presenting with spontaneous splenic rupture].
PG  - 1018-25
LID - 10.11406/rinketsu.57.1018 [doi]
AB  - A 48-year-old man was transferred to our emergency room because of sudden-onset 
      epigastric pain and nausea. Abdominal contrast-enhanced computed tomography (CT) 
      showed splenomegaly with splenic infarction and intra-abdominal bleeding, 
      suggestive of splenic rupture. An emergent open splenectomy was performed. His 
      spleen was markedly swollen and showed continuous bleeding due to a laceration. 
      On histopathological examination, his spleen was filled with abnormal tumor 
      cells. He was diagnosed as having mantle cell lymphoma based on the findings of 
      immunohistochemical and cytogenetic analyses of the spleen. Mantle cell lymphoma 
      cells were identified in the bone marrow and ileum, and he was determined to be 
      in stageIVA by positron emission tomography (PET)-CT. He was administered 
      rituximab combined with hyper-CVAD/MA chemotherapy (R-hyper-CVAD/MA regimen). 
      After two courses of the R-hyper-CVAD/MA regimen, he achieved complete response, 
      as confirmed by PET-CT. He received four courses in total of the R-hyper-CVAD/MA 
      regimen, followed sequentially by high-dose chemotherapy and autologous 
      peripheral blood stem cell transplantation (auto-PBSCT). He is currently alive 
      and free of disease. This is the 10(th) report of a mantle cell lymphoma case 
      with spontaneous splenic rupture. We herein review previous reports and emphasize 
      the importance of awareness of hematological malignancies when encountering a 
      case with spontaneous splenic rupture.
FAU - Maeda-Sakagami, Yukako
AU  - Maeda-Sakagami Y
AD  - Department of Clinical Immunology and Hematology, Nishi-Kobe Medical Center.
FAU - Tanaka, Yasuhiro
AU  - Tanaka Y
FAU - Koba, Yusuke
AU  - Koba Y
FAU - Shinzato, Isaku
AU  - Shinzato I
FAU - Ishikawa, Takayuki
AU  - Ishikawa T
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Humans
MH  - Lymphoma, Mantle-Cell/complications/diagnostic imaging/*therapy
MH  - Male
MH  - Middle Aged
MH  - Peripheral Blood Stem Cell Transplantation
MH  - Positron Emission Tomography Computed Tomography
MH  - Rupture, Spontaneous
MH  - Splenic Rupture/diagnostic imaging/*etiology
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2016/09/08 06:00
MHDA- 2017/02/12 06:00
CRDT- 2016/09/08 06:00
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2017/02/12 06:00 [medline]
AID - 10.11406/rinketsu.57.1018 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2016 Aug;57(8):1018-25. doi: 10.11406/rinketsu.57.1018.