PMID- 27599928
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20181202
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 193
DP  - 2016 Sep 25
TI  - Impact of porcine reproductive and respiratory syndrome virus and porcine 
      circovirus-2 infection on the potency of the classical swine fever vaccine (LOM 
      strain).
PG  - 36-41
LID - S0378-1135(16)30204-8 [pii]
LID - 10.1016/j.vetmic.2016.07.027 [doi]
AB  - The classical swine fever (CSF) vaccine, which is derived from the LOM strain of 
      the CSF virus (CSFV), induces protective immunity against CSFV infection. 
      However, several factors influence vaccine efficacy. Evidence suggests that 
      infection by porcine reproductive and respiratory syndrome virus (PRRSV) and/or 
      porcine circovirus 2 (PCV2) reduces the efficacy of several vaccines. Here, we 
      examined the effect of PRRSV or PCV2 alone or co-infection by PRRSV/PCV2 on the 
      potency of the LOM vaccine in pigs. Neither CSFV antibody levels nor the period 
      during which CSFV antigens were detectable in LOM-vaccinated pigs were negatively 
      affected by infection by PRRSV or PCV2. However, co-infection with PRRSV/PCV2 may 
      affect the replication or activity of the CSF vaccine virus in pigs vaccinated 
      with the LOM strain, although CSFV antibody levels were not negatively affected. 
      Nevertheless, the LOM vaccine afforded complete protection against a virulent 
      strain of CSFV.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Lim, Seong-In
AU  - Lim SI
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Jeoung, Hye-Young
AU  - Jeoung HY
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Kim, Byounghan
AU  - Kim B
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Song, Jae-Young
AU  - Song JY
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Kim, Jaejo
AU  - Kim J
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Kim, Ha-Young
AU  - Kim HY
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Cho, In-Soo
AU  - Cho IS
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea.
FAU - Woo, Gye-Hyeong
AU  - Woo GH
AD  - Department of Clinical Laboratory Science, Semyung University, Semyung-ro 65, 
      Jecheon, Chungbuk 390-711, South Korea.
FAU - Lee, Joong-Bok
AU  - Lee JB
AD  - College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, 
      Seoul, 143-701, Republic of Korea.
FAU - An, Dong-Jun
AU  - An DJ
AD  - Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of 
      Korea. Electronic address: andj67@korea.kr.
LA  - eng
PT  - Journal Article
DEP - 20160804
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Circoviridae Infections/immunology/*veterinary
MH  - Circovirus/immunology
MH  - Classical Swine Fever/immunology/*prevention & control
MH  - Classical Swine Fever Virus/*immunology
MH  - Coinfection
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Vaccination
MH  - Viral Vaccines/*immunology/standards
MH  - Virus Replication
OTO - NOTNLM
OT  - Classical swine fever virus
OT  - LOM strain
OT  - PCV2
OT  - PRRSV
EDAT- 2016/09/08 06:00
MHDA- 2017/05/16 06:00
CRDT- 2016/09/08 06:00
PHST- 2016/03/11 00:00 [received]
PHST- 2016/07/28 00:00 [revised]
PHST- 2016/07/31 00:00 [accepted]
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
AID - S0378-1135(16)30204-8 [pii]
AID - 10.1016/j.vetmic.2016.07.027 [doi]
PST - ppublish
SO  - Vet Microbiol. 2016 Sep 25;193:36-41. doi: 10.1016/j.vetmic.2016.07.027. Epub 
      2016 Aug 4.