PMID- 27600067
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160907
LR  - 20200929
IS  - 2076-3905 (Print)
IS  - 2076-3905 (Electronic)
IS  - 2076-3905 (Linking)
VI  - 5
IP  - 1
DP  - 2015 Dec 22
TI  - SNP Array in Hematopoietic Neoplasms: A Review.
LID - 10.3390/microarrays5010001 [doi]
LID - 1
AB  - Cytogenetic analysis is essential for the diagnosis and prognosis of 
      hematopoietic neoplasms in current clinical practice. Many hematopoietic 
      malignancies are characterized by structural chromosomal abnormalities such as 
      specific translocations, inversions, deletions and/or numerical abnormalities 
      that can be identified by karyotype analysis or fluorescence in situ 
      hybridization (FISH) studies. Single nucleotide polymorphism (SNP) arrays offer 
      high-resolution identification of copy number variants (CNVs) and acquired 
      copy-neutral loss of heterozygosity (LOH)/uniparental disomy (UPD) that are 
      usually not identifiable by conventional cytogenetic analysis and FISH studies. 
      As a result, SNP arrays have been increasingly applied to hematopoietic neoplasms 
      to search for clinically-significant genetic abnormalities. A large numbers of 
      CNVs and UPDs have been identified in a variety of hematopoietic neoplasms. CNVs 
      detected by SNP array in some hematopoietic neoplasms are of prognostic 
      significance. A few specific genes in the affected regions have been implicated 
      in the pathogenesis and may be the targets for specific therapeutic agents in the 
      future. In this review, we summarize the current findings of application of SNP 
      arrays in a variety of hematopoietic malignancies with an emphasis on the 
      clinically significant genetic variants.
FAU - Song, Jinming
AU  - Song J
AD  - Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer 
      Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. 
      Jinming.Song@moffitt.org.
FAU - Shao, Haipeng
AU  - Shao H
AD  - Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer 
      Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. 
      Haipeng.Shao@moffitt.org.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151222
PL  - Switzerland
TA  - Microarrays (Basel)
JT  - Microarrays (Basel, Switzerland)
JID - 101606493
PMC - PMC5003446
OTO - NOTNLM
OT  - SNP array
OT  - hematopoietic
OT  - leukemia
OT  - lymphoma
OT  - myelodysplastic syndrome
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
PMCR- 2015/12/22
CRDT- 2016/09/08 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2015/11/13 00:00 [revised]
PHST- 2015/12/14 00:00 [accepted]
PHST- 2016/09/08 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
PHST- 2015/12/22 00:00 [pmc-release]
AID - microarrays5010001 [pii]
AID - microarrays-05-00001 [pii]
AID - 10.3390/microarrays5010001 [doi]
PST - epublish
SO  - Microarrays (Basel). 2015 Dec 22;5(1):1. doi: 10.3390/microarrays5010001.