PMID- 27600808
OWN - NLM
STAT- MEDLINE
DCOM- 20190614
LR  - 20190614
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 12
IP  - 4
DP  - 2018 Aug
TI  - Early referral and comorbidity as possible causes of the declining transition 
      rate in subjects at clinical high risk for psychosis.
PG  - 596-604
LID - 10.1111/eip.12363 [doi]
AB  - AIM: A clinical high risk (CHR) for psychosis is regarded as the state of being 
      at risk of developing psychosis. However, the rate of transition to psychosis 
      among CHR subjects has been declining over time. We aimed to investigate the 
      effects of the possible causes of the declining transition rate. METHODS: A total 
      of 129 CHR subjects were divided into two groups according to the date of 
      enrollment: the 2005-2009 group and the 2009-2013 group. Baseline demographic and 
      clinical characteristics, including medication prescription, were compared. The 
      duration of untreated prodromal positive symptoms (DUPP) was used to account for 
      early referral. RESULTS: The transition rate to psychosis in the 2009-2013 group 
      was significantly lower than that in the 2005-2009 group (chi(2)  = 4.664, 
      P = 0.031), although the risk factors of transition, intelligence quotient and 
      prodromal positive symptoms did not differ between the two groups. When the DUPP 
      was added to the follow-up duration, the between-group difference in the 
      transition rates was no longer significant; however, the P-value was low (chi(2) 
       = 2.761, P = 0.097). After adjusting for axis II comorbidities other than 
      schizotypal personality disorder, the effect of group division on the transition 
      rate disappeared; however, the P-value was also low (P = 0.072). The mean 
      olanzapine equivalent dose and the proportion of subjects prescribed with 
      antidepressant or anxiolytic did not differ between the two groups. CONCLUSIONS: 
      Early referral and axis II comorbidities other than schizotypal personality 
      disorder were associated with the declining transition rate.
CI  - (c) 2016 John Wiley & Sons Australia, Ltd.
FAU - Lim, Kyung-Ok
AU  - Lim KO
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Republic of 
      Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Republic of 
      Korea.
FAU - Kim, Minah
AU  - Kim M
AD  - Department of Psychiatry, Seoul National University College of Medicine, Republic 
      of Korea.
FAU - Chon, Myong-Wuk
AU  - Chon MW
AD  - Department of Psychiatry, Seoul National University College of Medicine, Republic 
      of Korea.
FAU - Yun, Je-Yeon
AU  - Yun JY
AD  - Department of Psychiatry, Seoul National University College of Medicine, Republic 
      of Korea.
FAU - Kim, Sung Nyun
AU  - Kim SN
AD  - Department of Psychiatry, Seoul National University College of Medicine, Republic 
      of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Psychiatry, Seoul National University College of Medicine, Republic 
      of Korea.
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Republic of Korea.
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160907
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Comorbidity
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*epidemiology
MH  - Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/*epidemiology
MH  - *Referral and Consultation
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - comorbidity
OT  - prodromal symptoms
OT  - psychosis
OT  - referral.
EDAT- 2016/09/08 06:00
MHDA- 2019/06/15 06:00
CRDT- 2016/09/08 06:00
PHST- 2015/08/06 00:00 [received]
PHST- 2016/06/12 00:00 [accepted]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2019/06/15 06:00 [medline]
PHST- 2016/09/08 06:00 [entrez]
AID - 10.1111/eip.12363 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2018 Aug;12(4):596-604. doi: 10.1111/eip.12363. Epub 
      2016 Sep 7.