PMID- 2760158
OWN - NLM
STAT- MEDLINE
DCOM- 19890915
LR  - 20190629
VI  - 490
IP  - 1
DP  - 1989 May 5
TI  - Determination of 3,4-methylenedioxyamphetamine and 
      3,4-methylenedioxymethamphetamine enantiomers in whole blood.
PG  - 59-69
AB  - A method for the determination of the enantiomeric content of 
      3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) 
      in microsamples (200 microliters) of whole blood is described. The method 
      involves liquid-liquid extraction of MDA and MDMA from blood and derivatization 
      with the chiral reagent N-trifluoroacetyl-L-prolyl chloride. Separation, 
      identification and quantitation of diastereomeric derivatives is by gas 
      chromatography-mass spectrometry. The analytical range of the assay is from 0.12 
      ng to 48 ng injected on-column. Details for the synthesis of the enantiomers of 
      MDMA are also provided.
FAU - Fitzgerald, R L
AU  - Fitzgerald RL
AD  - Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond 
      23298.
FAU - Blanke, R V
AU  - Blanke RV
FAU - Glennon, R A
AU  - Glennon RA
FAU - Yousif, M Y
AU  - Yousif MY
FAU - Rosecrans, J A
AU  - Rosecrans JA
FAU - Poklis, A
AU  - Poklis A
LA  - eng
GR  - 5T32DA07027/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Chromatogr
JT  - Journal of chromatography
JID - 0427043
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*blood
MH  - Amphetamines/*blood
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - Mass Spectrometry
MH  - Stereoisomerism
EDAT- 1989/05/05 00:00
MHDA- 1989/05/05 00:01
CRDT- 1989/05/05 00:00
PHST- 1989/05/05 00:00 [pubmed]
PHST- 1989/05/05 00:01 [medline]
PHST- 1989/05/05 00:00 [entrez]
AID - 10.1016/s0378-4347(00)82761-9 [doi]
PST - ppublish
SO  - J Chromatogr. 1989 May 5;490(1):59-69. doi: 10.1016/s0378-4347(00)82761-9.