PMID- 27602125
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 12
IP  - 3
DP  - 2016 Sep
TI  - A rare case of a three way complex variant positive Philadelphia translocation 
      involving chromosome (9;11;22)(q34;p15;q11) in chronic myeloid leukemia: A case 
      report.
PG  - 1986-1988
AB  - The t(9;22)(q34;q11) translocation is present in 90-95% of patients with chronic 
      myeloid leukemia (CML). Variant complex translocations have been observed in 5-8% 
      of CML patients, in which a third chromosome other than (9;22) is involved. 
      Imatinib mesylate is the first line breakpoint cluster region-Abelson gene 
      (BCR/ABL)-targeted oral therapy for CML, and may produce a complete response in 
      70-80% of CML patients in the chronic phase. In the present study, a bone marrow 
      sample was used for conventional cytogenetic analysis, and the fluorescence in 
      situ hybridization (FISH) test was used for BCR/ABL gene detection. A 
      hematological analysis was also performed to determine the white blood cell (WBC) 
      count, red blood cell count, hemoglobin levels, packed and mean cell volumes, 
      mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and 
      platelet values of the patient. The hematological analysis of the patient 
      indicated the increased WBC of 186.5x10(3) cells/microl, and decreased hemoglobin 
      levels of 11.1 g/dl. The FISH test revealed that 67% cells demonstrated BCR/ABL 
      gene translocation. The patient was treated with 400 mg imatinib mesylate daily, 
      and was monitored at various intervals over a 6-month period. The present study 
      reports the rare case of a patient that demonstrates a three-way Philadelphia 
      chromosome-positive translocation involving 46XY,t(9;11;22)(q34;p15;q11)[10], 
      alongside CML in the chronic phase. The translocation was analyzed using 
      cytogenetic and FISH tests.
FAU - Asif, Muhammad
AU  - Asif M
AD  - Department of Biotechnology and Informatics, Balochistan University of 
      Information Technology, Engineering and Management Sciences, Quetta, Balochistan 
      87300, Pakistan; Office of Research Innovation and Commercialization, Balochistan 
      University of Information Technology, Engineering and Management Sciences, 
      Quetta, Balochistan 87300, Pakistan.
FAU - Hussain, Abrar
AU  - Hussain A
AD  - Department of Biotechnology and Informatics, Balochistan University of 
      Information Technology, Engineering and Management Sciences, Quetta, Balochistan 
      87300, Pakistan.
FAU - Rasool, Mahmood
AU  - Rasool M
AD  - Center of Excellence in Genomic Medicine Research, King Abdulaziz University, 
      Jeddah, Makkah 21589, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20160707
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4998593
OTO - NOTNLM
OT  - breakpoint cluster region-Abelson gene
OT  - chronic myeloid leukemia
OT  - variant complex translocation
EDAT- 2016/09/08 06:00
MHDA- 2016/09/08 06:01
PMCR- 2016/07/07
CRDT- 2016/09/08 06:00
PHST- 2015/01/31 00:00 [received]
PHST- 2015/12/02 00:00 [accepted]
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2016/09/08 06:01 [medline]
PHST- 2016/07/07 00:00 [pmc-release]
AID - OL-0-0-4821 [pii]
AID - 10.3892/ol.2016.4821 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Sep;12(3):1986-1988. doi: 10.3892/ol.2016.4821. Epub 2016 Jul 7.