PMID- 27602188
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160907
LR  - 20200928
IS  - 1999-768X (Print)
IS  - 2070-5204 (Electronic)
IS  - 1999-768X (Linking)
VI  - 31
IP  - 5
DP  - 2016 Sep
TI  - Can a Six-Minute Walk Distance Predict Right Ventricular Dysfunction in Patients 
      with Diffuse Parenchymal Lung Disease and Pulmonary Hypertension?
PG  - 345-51
LID - 10.5001/omj.2016.69 [doi]
AB  - OBJECTIVES: Pulmonary hypertension (PH) is commonly observed in patients with 
      diffuse parenchymal lung disease (DPLD). The purpose of this study was to explore 
      the influence of the 6-minute walk test (6MWT) as a simple, non-invasive tool to 
      assess right ventricular (RV) function in patients with DPLD and to identify the 
      need for an echocardiogram (ECHO) to screen for PH. METHODS: We retrospectively 
      reviewed 48 patients with PH secondary to DPLD, who were evaluated in the PH 
      clinic at the Mayo Clinic in Jacksonville, Florida, from January 1999 to December 
      2014. RESULTS: Fifty-two percent of patients had RV dysfunction. They had a 
      significantly greater right heart pressure by ECHO and mean pulmonary arterial 
      pressure (MPAP) from right heart catheterization (RHC) than those with normal RV 
      function. A reduced 6-minute walk distance (6MWD) did not predict RV dysfunction 
      (OR 0.995; 95% CI 0.980-1.001, p = 0.138). In addition, worsening restrictive 
      physiology, heart rate at one-minute recovery and desaturation were not different 
      between patients with and without RV dysfunction. However, there were inverse 
      correlations between 6MWD and MPAP from RHC (r = -0.41, 
p = 0.010), 6MWD and RV 
      systolic pressure (r = -0.51, p < 0.001), and 6MWD and MPAP measured by ECHO (r = 
      -0.46, p =0.013). We also found no significant correlation between 6MWD and 
      pulmonary function test parameters. CONCLUSIONS: Our single-center cohort of 
      patients with PH secondary to DPLD, PH was found to have an impact on 6MWD. In 
      contrast to our expectations, 6MWD was not useful to predict RV dysfunction. 
      Interestingly, a severe reduction in the 6MWD was related to PH and not to 
      pulmonary function; therefore, it may be used to justify an ECHO to identify 
      patients with a worse prognosis.
FAU - Ussavarungsi, Kamonpun
AU  - Ussavarungsi K
AD  - Pulmonary Medicine, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Lee, Augustine S
AU  - Lee AS
AD  - Pulmonary Medicine, Mayo Clinic, Jacksonville, Florida, USA.
FAU - Burger, Charles D
AU  - Burger CD
AD  - Pulmonary Medicine, Mayo Clinic, Jacksonville, Florida, USA.
LA  - eng
PT  - Journal Article
PL  - Oman
TA  - Oman Med J
JT  - Oman medical journal
JID - 101526350
PMC - PMC4996956
OTO - NOTNLM
OT  - 6-minute walk distance
OT  - Diffuse Parenchymal Lung Diseases
OT  - Echocardiogram.
OT  - Interstitial Lung Diseases
OT  - Pulmonary Hypertension
EDAT- 2016/09/08 06:00
MHDA- 2016/09/08 06:01
PMCR- 2016/09/01
CRDT- 2016/09/08 06:00
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2016/09/08 06:01 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - OMJ-D-15-00155 [pii]
AID - 10.5001/omj.2016.69 [doi]
PST - ppublish
SO  - Oman Med J. 2016 Sep;31(5):345-51. doi: 10.5001/omj.2016.69.