PMID- 27602574
OWN - NLM
STAT- MEDLINE
DCOM- 20170804
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 9
DP  - 2016
TI  - Cigarette Smoke Induces Immune Responses to Vimentin in both, 
      Arthritis-Susceptible and -Resistant Humanized Mice.
PG  - e0162341
LID - 10.1371/journal.pone.0162341 [doi]
LID - e0162341
AB  - Rheumatoid arthritis (RA) is an autoimmune disease marked by chronic synovial 
      inflammation and both, genetic and environmental factors are involved in its 
      pathogenesis. Human leukocyte antigen (HLA) DRB1*0401 is associated with 
      susceptibility to develop RA, while cigarette smoke (CS) exposure promotes 
      seropositive disease with increased severity in DRB1*0401+ individuals. Smokers 
      have higher levels of antibodies against citrullinated peptides. In this study, 
      we determined whether the response to a known autoantigen, Vimentin (Vim) is 
      shared epitope specific and how CS influences this response using transgenic-mice 
      carrying RA-susceptible,*0401, and -resistant, *0402, genes. Following relatively 
      brief exposure to CS, peptidyl arginine deiminase (PAD) enzyme expression was 
      increased in murine lungs. Cigarette smoking led to production of Interferon 
      (IFN)-gamma with reduced levels of Interleukin (IL)-10 by splenocytes of *0401 mice. 
      In contrast, CS augmented Th2 cytokines along with T-regulatory cells in *0402 
      mice. An increase in levels of antibodies to native and citrullinated Vim was 
      observed in naive mice of both strains following CS exposure. Our data showed 
      that both arthritis-susceptible and -resistant mice can generate cellular and 
      humoral immunity to Vim; however CS-induced modulation of host immunity is 
      dependent on the interaction with the host HLA genes.
FAU - Bidkar, Mitali
AU  - Bidkar M
AD  - Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of 
      America.
FAU - Vassallo, Robert
AU  - Vassallo R
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
FAU - Luckey, David
AU  - Luckey D
AD  - Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of 
      America.
FAU - Smart, Michele
AU  - Smart M
AD  - Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of 
      America.
FAU - Mouapi, Kelly
AU  - Mouapi K
AD  - Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of 
      America.
FAU - Taneja, Veena
AU  - Taneja V
AUID- ORCID: 0000-0003-2401-694X
AD  - Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of 
      America.
AD  - Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of 
      America.
LA  - eng
GR  - R01 AR030752/AR/NIAMS NIH HHS/United States
GR  - R21 AR060077/AR/NIAMS NIH HHS/United States
GR  - R56 AR030752/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20160907
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cytokines)
RN  - 0 (Epitopes)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Vimentin)
RN  - EC 3.- (Hydrolases)
RN  - EC 3.5.3.15 (Protein-Arginine Deiminases)
SB  - IM
CIN - Nat Rev Rheumatol. 2016 Nov;12 (11):624. PMID: 27652505
MH  - Animals
MH  - Arthritis, Rheumatoid/enzymology/genetics/*immunology
MH  - Cell Proliferation
MH  - Cytokines/metabolism
MH  - Disease Resistance/genetics/*immunology
MH  - Disease Susceptibility
MH  - Epitopes/immunology
MH  - Female
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Hydrolases/metabolism
MH  - Immunity, Humoral
MH  - Lung/enzymology/pathology
MH  - Lymphocyte Count
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Protein-Arginine Deiminases
MH  - Smoking/*adverse effects
MH  - T-Lymphocytes/immunology
MH  - Vimentin/*immunology
PMC - PMC5014446
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/09/08 06:00
MHDA- 2017/08/05 06:00
PMCR- 2016/09/07
CRDT- 2016/09/08 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2016/08/22 00:00 [accepted]
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2016/09/07 00:00 [pmc-release]
AID - PONE-D-16-17440 [pii]
AID - 10.1371/journal.pone.0162341 [doi]
PST - epublish
SO  - PLoS One. 2016 Sep 7;11(9):e0162341. doi: 10.1371/journal.pone.0162341. 
      eCollection 2016.