PMID- 27603300
OWN - NLM
STAT- MEDLINE
DCOM- 20170623
LR  - 20170817
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 28
IP  - 12
DP  - 2016 Dec
TI  - Transient remission of nonalcoholic fatty liver disease decreases the risk of 
      incident type 2 diabetes mellitus in Japanese men.
PG  - 1443-1449
AB  - INTRODUCTION: It is unclear how the transient remission of nonalcoholic fatty 
      liver disease (NAFLD) affects incident type 2 diabetes mellitus (T2DM). Here, we 
      sought to determine the effect of the transient remission of NAFLD on incident 
      T2DM in Japanese men. MATERIALS AND METHODS: We used a population-based health 
      check-up program. The primary outcome was set as incident T2DM. We divided the 
      participants who showed NAFLD at the time of enrollment into three groups 
      according to their clinical course of NAFLD: the Regression group, in which the 
      participants showed a regression of NAFLD and no relapse during the follow-up 
      period; the Transient Remission group, in which participants achieved a transient 
      remission of NAFLD, but had a relapse of NAFLD; and the Persistent group, in 
      which participants showed NAFLD throughout the follow-up. The Never group of 
      participants who did not show NAFLD throughout the follow-up served as a 
      reference. RESULTS: The incidence rates of T2DM in the Never group, the 
      Regression group, the Transient Remission group, and the Persistent group were 
      4.7% (62/1306), 9.2% (14/153), 18.0% (25/139), and 35.1% (120/342), respectively. 
      In a multivariate Cox regression analysis with covariates, the adjusted hazard 
      ratios for incident T2DM compared with the Never group were as follows: 
      Regression group: 1.08 [95% confidence interval (CI) 0.53-2.04, P=0.81], 
      Transient Remission group: 2.12 (95% CI 1.22-3.57, P<0.01), and Persistent group: 
      3.44 (95% CI 2.29-5.21, P<0.001). The adjusted hazard ratio of the Transient 
      Remission group was significantly lower than that of the Persistent group 
      (P<0.05). CONCLUSION: Transient remission of NAFLD significantly decreased the 
      risk of developing T2DM.
FAU - Fukuda, Takuya
AU  - Fukuda T
AD  - aDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, 
      Kyoto Prefectural University of Medicine bDepartment of Diabetology, Kameoka 
      Municipal Hospital cDepartment of Internal Medicine, Aiseikai Yamashina Hospital, 
      Kyoto dDepartment of Gastroenterology, Murakami Memorial Hospital, Asahi 
      University, Gifu, Japan.
FAU - Hamaguchi, Masahide
AU  - Hamaguchi M
FAU - Kojima, Takao
AU  - Kojima T
FAU - Mitsuhashi, Kazuteru
AU  - Mitsuhashi K
FAU - Hashimoto, Yoshitaka
AU  - Hashimoto Y
FAU - Ohbora, Akihiro
AU  - Ohbora A
FAU - Kato, Takahiro
AU  - Kato T
FAU - Nakamura, Naoto
AU  - Nakamura N
FAU - Fukui, Michiaki
AU  - Fukui M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Liver/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Non-alcoholic Fatty Liver Disease/diagnostic 
      imaging/*epidemiology/physiopathology
MH  - Proportional Hazards Models
MH  - Recurrence
MH  - *Remission, Spontaneous
MH  - Risk Factors
MH  - Ultrasonography
EDAT- 2016/10/21 06:00
MHDA- 2017/06/24 06:00
CRDT- 2016/09/08 06:00
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
PHST- 2016/09/08 06:00 [entrez]
AID - 10.1097/MEG.0000000000000736 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1443-1449. doi: 
      10.1097/MEG.0000000000000736.