PMID- 27603702
OWN - NLM
STAT- MEDLINE
DCOM- 20170918
LR  - 20170918
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 92
IP  - 4
DP  - 2016
TI  - Transthoracic Echocardiography and Chest Computed Tomography Arteriography in 
      Patients with Acute Pulmonary Embolism: A Two-Year Follow-Up Study.
PG  - 235-240
AB  - BACKGROUND: Pulmonary hypertension (PH) is frequently found at the time of 
      diagnosis of pulmonary embolism (PE). An incomplete resolution of PE can lead to 
      chronic thromboembolic pulmonary hypertension (CTPH). Transthoracic 
      echocardiogram (TTE) is the first step to diagnose an abnormality of the 
      pulmonary vasculature. Based on computed tomography (CT), the Qanadli vascular 
      obstruction index has been extensively used to assess acute PE. OBJECTIVES: Our 
      aim was to ascertain whether at the time of diagnosis of an acute PE episode TTE 
      variables and a Qanadli CT index score may be associated with CTPH 2 years later. 
      METHOD: Patients with PE were prospectively enrolled. TTE was performed and the 
      Qanadli CT obstruction index was calculated on admission to the hospital, while 
      only TTE was repeated at the 2-year follow-up. The NYHA (New York Heart 
      Association) functional classification was evaluated. Correlation analyses were 
      performed. RESULTS: Twenty patients (11 males, median age 69.5 years) were 
      considered for the study. There was no significant correlation between TTE 
      parameters and the Qanadli CT obstruction index. A significant distribution (chi2 = 
      5.69, p = 0.017) was found in the analysis among patients with CTPH at 24 months 
      and the Qanadli CT index, categorized by a receiver operating characteristic 
      curve cutoff value of 42.5%. Additionally, a significant distribution (chi2 = 4.09, 
      p = 0.043) was found in the analysis among patients with CTPH at 24 months and 
      right ventricular systolic pressure on admission, categorized as PH (>31 mm Hg). 
      CONCLUSION: Our study demonstrates that in patients with acute PE there is no 
      relationship between the Qanadli CT obstruction index and TTE parameters on 
      admission to the hospital. However, the occurrence of CTPH at the 24-month 
      follow-up is associated with PH and with a high Qanadli CT obstruction index 
      score.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Serra, Walter
AU  - Serra W
AD  - Cardiology Unit, Department of Surgery, University Hospital of Parma, Parma, 
      Italy.
FAU - Crisafulli, Ernesto
AU  - Crisafulli E
FAU - Sverzellati, Nicola
AU  - Sverzellati N
FAU - Ugolotti, P Tito
AU  - Ugolotti PT
FAU - Tzani, Panajota
AU  - Tzani P
FAU - Marangio, Emilio
AU  - Marangio E
FAU - Ardissino, Diego
AU  - Ardissino D
FAU - Gherli, Tiziano
AU  - Gherli T
FAU - Chetta, Alfredo
AU  - Chetta A
LA  - eng
PT  - Journal Article
DEP - 20160908
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Chronic Disease
MH  - Computed Tomography Angiography
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Artery/*diagnostic imaging
MH  - Pulmonary Embolism/*diagnostic imaging
MH  - ROC Curve
MH  - Tomography, X-Ray Computed
EDAT- 2016/09/08 06:00
MHDA- 2017/09/19 06:00
CRDT- 2016/09/08 06:00
PHST- 2015/06/24 00:00 [received]
PHST- 2016/07/25 00:00 [accepted]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2017/09/19 06:00 [medline]
PHST- 2016/09/08 06:00 [entrez]
AID - 000448687 [pii]
AID - 10.1159/000448687 [doi]
PST - ppublish
SO  - Respiration. 2016;92(4):235-240. doi: 10.1159/000448687. Epub 2016 Sep 8.