PMID- 27603724
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20190221
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 11
DP  - 2016 Sep 1
TI  - Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy 
      Compared to Open-Angle Glaucoma.
PG  - 4632-40
LID - 10.1167/iovs.16-19442 [doi]
AB  - PURPOSE: To compare optic nerve head (ONH) morphology of optic nerve atrophy 
      between eyes with primary open-angle glaucoma (POAG) and eyes with a history of 
      nonarteritic anterior ischemic optic atrophy (NAION) using enhanced depth imaging 
      (EDI) with spectral-domain optical coherence tomography (SD-OCT). METHODS: In 
      this cross-sectional study, 121 eyes of 91 patients consisted of moderate to 
      severe POAG (n = 32 eyes), visual field mean deviation-matched NAION (n = 30 
      eyes) and their fellow eyes (n = 30 eyes), and healthy controls (n = 29). The 
      optic discs were scanned using SD-OCT and measurements were obtained using HEYEX 
      software 6.0. Lamina cribrosa (LC) thickness and anterior lamina cribrosa depth 
      (ALD) at three scans (midsuperior, central, and midinferior) were determined and 
      compared. In addition, prelaminar tissue thickness was measured at three points 
      of a single central scan. RESULTS: There was no significant difference in the 
      visual field mean deviation (MD) between the NAION and POAG groups (P > 0.99), 
      but both groups had a significantly worse MD than the healthy group (P < 0.001). 
      The NAION and POAG groups had similar peripapillary retinal nerve fiber layer 
      (pRNFL) thickness (P < 0.99). Eyes with POAG had greater ALD and thinner LC than 
      control eyes and NAION eyes in all regions of the ONH (P < 0.001 for both). There 
      was a marked prelaminar tissue thinning in POAG eyes compared to control and 
      NAION eyes (P < 0.001). Lamina cribrosa thickness and ALD of NAION eyes were not 
      different from their fellow eyes and control eyes. Although prelaminar thickness 
      was thinner in NAION eyes compared to their fellow eyes (P = 0.005), it was 
      thicker than in control eyes (P < 0.001). CONCLUSIONS: Despite profound thinning 
      and posterior displacement of LC in POAG, the thickness and position of LC in 
      NAION eyes are similar to those seen in healthy control and their fellow eyes.
FAU - Fard, Masoud Aghsaei
AU  - Fard MA
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Afzali, Marjan
AU  - Afzali M
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Abdi, Parisa
AU  - Abdi P
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Chen, Rebecca
AU  - Chen R
AD  - Case Western Reserve University School of Medicine, Cleveland, Ohio, United 
      States 3Department of Ophthalmology, University of California-San Francisco, San 
      Francisco, California, United States.
FAU - Yaseri, Mehdi
AU  - Yaseri M
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran 4Department of Epidemiology and Biostatistics, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Azaripour, Ebrahim
AU  - Azaripour E
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Moghimi, Sasan
AU  - Moghimi S
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran 3Department of Ophthalmology, University of California-San 
      Francisco, San Francisco, California, United States.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - Image Enhancement
MH  - *Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Optic Neuropathy, Ischemic/*diagnosis/physiopathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Fields
EDAT- 2016/09/08 06:00
MHDA- 2017/05/27 06:00
CRDT- 2016/09/08 06:00
PHST- 2016/09/08 06:00 [entrez]
PHST- 2016/09/08 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
AID - 2552273 [pii]
AID - 10.1167/iovs.16-19442 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4632-40. doi: 10.1167/iovs.16-19442.