PMID- 27604550
OWN - NLM
STAT- MEDLINE
DCOM- 20171020
LR  - 20220330
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 14
IP  - 1
DP  - 2016 Sep 7
TI  - Triglyceride glucose-waist circumference, a novel and effective predictor of 
      diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional 
      and prospective cohort study.
PG  - 260
LID - 10.1186/s12967-016-1020-8 [doi]
LID - 260
AB  - BACKGROUND: Body mass index (BMI), waist circumference (WC), visceral adiposity 
      index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been 
      reported as markers of insulin resistance or type 2 diabetes mellitus (T2DM). 
      However, little is known about the associations between the aforementioned 
      markers and the risk of prediabetes and diabetes in first-degree relatives (FDRs) 
      of T2DM patients. METHODS: 1544 FDRs of T2DM patients (635 men and 909 women) 
      were enrolled in the initial cross-sectional study and all of them finished 
      corresponding examinations. Logistic regression analysis and receiver operating 
      characteristic (ROC) curve were used to compare and identify the associations of 
      the six parameters (BMI, WC, VAI, TyG, TyG-BMI and TyG-WC) with the prevalence of 
      prediabetes and diabetes. Subsequently, 452 of them were followed-up for an 
      average of 5 years. Cox proportional hazard regression model was applied to 
      confirm the predictive value of the optimal marker. RESULTS: Among the indices, 
      TyG-WC was more strongly associated with the prevalence of prediabetes and 
      diabetes. Compared with participants in the lowest quartile of TyG-WC, the 
      adjusted odds ratio and 95 % CIs for prediabetes and diabetes was 11.19 
      (7.62-16.42) for those in the top quartile of TyG-WC. Moreover, the largest AUC 
      was also observed in TyG-WC (0.765, 95 % CIs 0.741-0.789, P < 0.001). The robust 
      predictive value of TyG-WC was further confirmed in the follow-up study (HR: 
      7.13, 95 % CIs 3.41-14.90, P < 0.001). CONCLUSIONS: TyG-WC is a novel and 
      clinically effective marker for early identifying the risks of prediabetes and 
      diabetes in FDRs of T2DM patients.
FAU - Zheng, Shuang
AU  - Zheng S
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Shi, Sheng
AU  - Shi S
AD  - Department of Orthopedic Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Ren, Xingxing
AU  - Ren X
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Han, Tingting
AU  - Han T
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Li, Yangxue
AU  - Li Y
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Chen, Yawen
AU  - Chen Y
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China.
FAU - Hou, Peter C
AU  - Hou PC
AD  - Department of Emergency Medicine, Brigham and Women's Hospital and Harvard 
      Medical School, Boston, MA, USA.
FAU - Hu, Yaomin
AU  - Hu Y
AD  - Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai 
      Jiaotong University, No.160 Pujian Road, Shanghai, 200127, China. 
      amin1031@sina.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160907
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*diagnosis/*metabolism
MH  - *Family
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prediabetic State/diagnosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Triglycerides/*metabolism
MH  - *Waist Circumference
PMC - PMC5015232
OTO - NOTNLM
OT  - First-degree relative
OT  - Triglyceride glucose index
OT  - TyG-WC
OT  - Type 2 diabetes mellitus
OT  - Visceral adiposity index
EDAT- 2016/09/09 06:00
MHDA- 2017/10/21 06:00
PMCR- 2016/09/07
CRDT- 2016/09/09 06:00
PHST- 2016/06/15 00:00 [received]
PHST- 2016/08/26 00:00 [accepted]
PHST- 2016/09/09 06:00 [entrez]
PHST- 2016/09/09 06:00 [pubmed]
PHST- 2017/10/21 06:00 [medline]
PHST- 2016/09/07 00:00 [pmc-release]
AID - 10.1186/s12967-016-1020-8 [pii]
AID - 1020 [pii]
AID - 10.1186/s12967-016-1020-8 [doi]
PST - epublish
SO  - J Transl Med. 2016 Sep 7;14(1):260. doi: 10.1186/s12967-016-1020-8.